Molecular cloning and expression of mouse homologue of SFA-1/PETA-3 (CD151), a member of the transmembrane 4 superfamily.

We have isolated mouse SFA-1 (CD151) cDNA from a mouse myelomonocytic leukemia cell line, WEHI-3. Mouse CD151 mRNA comprises approximately 1.8 kb, has 253 amino acid residues with 93% identity to human CD151 and contains four putative transmembrane domains, a number of cysteine residues and one potential N-glycosylation site located at a site corresponding to that in human CD151. Mouse CD151 gene expression was observed in many cell types, but was either absent or present at a low level in brain and lymphoid cells and tissues, including thymus and spleen. The expression patterns of mouse and human CD151 genes are similar.