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Literature DB >> 9294

In vitro stability of proscillaridin A.

Abstract

In an in vitro study, proscillardin A was found to be rapidly inactivated at low pH. More than 50 per cent of its activity, measured by 86Rb assay, was lost after incubation for 15 minutes at pH 1 and 37 degrees C. Compared with proscillaridin, the rate of inactivation of digoxin was lower in these experiments. The rapid inactivation of proscillaridin might be of clinical importance when treating patients with this glycoside.

Entities: Chemical Species

Mesh：

Substances：

Year: 1975 PMID： 9294 DOI： 10.1007/BF00561563

Source DB: PubMed Journal: Eur J Clin Pharmacol ISSN： 0031-6970 Impact factor: 2.953

12 in total

1. [ON THE PHARMACOLOGY OF A PURE GLYCOSIDE RECENTLY INTRODUCED INTO THERAPY].

Authors: H G KURBJUWEIT
Journal: Arzneimittelforschung Date: 1964-06

2. [CLINICAL EXPERIENCES WITH TALUSIN].

Authors: W GEBHARDT; H REINDELL; J HEINING; C BUECHNER; D DANNER; F MOSER; F WOEHLER; G HOFFMANN; G WINCKELMANN
Journal: Med Klin Date: 1965-05-28

3. The effect of various cardenolides and bufadienolides with different cardiac activity on the 86-rubidium uptake of human erythrocytes.

Authors: G G Belz; G B Stauch; H G Kurbjuweit; A Oberdorf
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1973 Impact factor: 3.000

4. [The inhibitory effect of cardiac glycosides on 86 Rb-uptake of erythrocytes. II. Specificity of the inhibitory effect with special attention to cymarin (k-strophantin-a) and its derivatives].

Authors: K O Vollmer; J H Wissler; G G Belz
Journal: Eur J Clin Pharmacol Date: 1972-03 Impact factor: 2.953

5. Cleavage of glycosidic bonds of digoxin and derivatives as function of pH and time.

Authors: J Kuhlmann; U Abshagen; N Rietbrock
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1973 Impact factor: 3.000

6. The influence of metabolites of digoxin and digitoxin on the 86Rb-uptake assay.

Authors: J M Kaufman; F M Belpaire
Journal: Eur J Clin Pharmacol Date: 1973-06 Impact factor: 2.953

7. [Influence of digestive juices on hhe stability of the digoxin and digitoxin molecule].

Authors: K Kasahara; A Ruiz-Torres
Journal: Klin Wochenschr Date: 1969-10-15

8. [Clinical experimental studies with the heart glycoside, proscillaridin, with special reference to its enteral resorption rate].

Authors: G G Belz
Journal: Med Klin Date: 1968-01-19

In vitro stability of proscillaridin A.

1. [ON THE PHARMACOLOGY OF A PURE GLYCOSIDE RECENTLY INTRODUCED INTO THERAPY].

2. [CLINICAL EXPERIENCES WITH TALUSIN].

3. The effect of various cardenolides and bufadienolides with different cardiac activity on the 86-rubidium uptake of human erythrocytes.

4. [The inhibitory effect of cardiac glycosides on 86 Rb-uptake of erythrocytes. II. Specificity of the inhibitory effect with special attention to cymarin (k-strophantin-a) and its derivatives].

5. Cleavage of glycosidic bonds of digoxin and derivatives as function of pH and time.

6. The influence of metabolites of digoxin and digitoxin on the 86Rb-uptake assay.

7. [Influence of digestive juices on hhe stability of the digoxin and digitoxin molecule].

8. [Clinical experimental studies with the heart glycoside, proscillaridin, with special reference to its enteral resorption rate].

9. An improved method of estimating digoxin in human plasma.

10. [Therapeutic experiences with a new cardiac glycoside: proscillaridin A].

1. On the pharmacokinetics of proscillaridin A in man.

2. Proscillaridin activity in portal and peripheral venous blood after oral administration to man.

3. Biliary excretion and enterochepatic recycling of proscillaridin A after oral adminstration to man.

4. Stability in vitro of methylproscillaridin.