Literature DB >> 9293157

Negative signaling in B cells: SHIP Grbs Shc.

S Tridandapani1, T Kelley, D Cooney, M Pradhan, K M Coggeshall.   

Abstract

Negative signaling in B cells is initiated by co-crosslinking of the antigen receptor and the Fcy receptor, resulting in cessation of B-cell signaling events and, in turn, inhibiting B-cell proliferation and antibody secretion. Here, a competitive role is proposed for SHIP in blocking the interaction of Shc with the Grb2-Sos complex of proteins that lead to Ras activation in B cells.

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Year:  1997        PMID： 9293157     DOI： 10.1016/s0167-5699(97)01112-2

Source DB:  PubMed          Journal:  Immunol Today        ISSN： 0167-5699


  11 in total

Review 1.  Negative signaling in health and disease.

Authors:  K M Coggeshall
Journal:  Immunol Res       Date:  1999       Impact factor: 2.829

2.  FcgammaR-induced production of superoxide and inflammatory cytokines is differentially regulated by SHIP through its influence on PI3K and/or Ras/Erk pathways.

Authors:  Latha P Ganesan; Trupti Joshi; Huiqing Fang; Vijay Kumar Kutala; Julie Roda; Rossana Trotta; Amy Lehman; Periannan Kuppusamy; John C Byrd; William E Carson; Michael A Caligiuri; Susheela Tridandapani
Journal:  Blood       Date:  2006-03-16       Impact factor: 22.113

3.  DSHP: a "power bar" for sustained immune responses?

Authors:  A B Satterthwaite; D J Rawlings; O N Witte
Journal:  Proc Natl Acad Sci U S A       Date:  1998-11-10       Impact factor: 11.205

4.  Visualization of negative signaling in B cells by quantitative confocal microscopy.

Authors:  H Phee; W Rodgers; K M Coggeshall
Journal:  Mol Cell Biol       Date:  2001-12       Impact factor: 4.272

5.  pp60c-src associates with the SH2-containing inositol-5-phosphatase SHIP1 and is involved in its tyrosine phosphorylation downstream of alphaIIbbeta3 integrin in human platelets.

Authors:  S Giuriato; S Bodin; C Erneux; R Woscholski; M Plantavid; H Chap; B Payrastre
Journal:  Biochem J       Date:  2000-05-15       Impact factor: 3.857

6.  Targeted disruption of SHIP leads to hemopoietic perturbations, lung pathology, and a shortened life span.

Authors:  C D Helgason; J E Damen; P Rosten; R Grewal; P Sorensen; S M Chappel; A Borowski; F Jirik; G Krystal; R K Humphries
Journal:  Genes Dev       Date:  1998-06-01       Impact factor: 11.361

7.  T cell-specific deletion of the inositol phosphatase SHIP reveals its role in regulating Th1/Th2 and cytotoxic responses.

Authors:  Tatyana Tarasenko; Hemanta K Kole; Anthony W Chi; Margaret M Mentink-Kane; Thomas A Wynn; Silvia Bolland
Journal:  Proc Natl Acad Sci U S A       Date:  2007-06-21       Impact factor: 11.205

8.  Macrophage pro-inflammatory response to Francisella novicida infection is regulated by SHIP.

Authors:  Kishore V L Parsa; Latha P Ganesan; Murugesan V S Rajaram; Mikhail A Gavrilin; Ashwin Balagopal; Nrusingh P Mohapatra; Mark D Wewers; Larry S Schlesinger; John S Gunn; Susheela Tridandapani
Journal:  PLoS Pathog       Date:  2006-07       Impact factor: 6.823

9.  Evidence for SH2 domain-containing 5'-inositol phosphatase-2 (SHIP2) contributing to a lymphatic dysfunction.

Authors:  Germaine D Agollah; Manuel L Gonzalez-Garay; John C Rasmussen; I-Chih Tan; Melissa B Aldrich; Chinmay Darne; Caroline E Fife; Renie Guilliod; Erik A Maus; Philip D King; Eva M Sevick-Muraca
Journal:  PLoS One       Date:  2014-11-10       Impact factor: 3.240

10.  The inositol polyphosphate 5-phosphatase ship is a crucial negative regulator of B cell antigen receptor signaling.

Authors:  Q Liu; A J Oliveira-Dos-Santos; S Mariathasan; D Bouchard; J Jones; R Sarao; I Kozieradzki; P S Ohashi; J M Penninger; D J Dumont
Journal:  J Exp Med       Date:  1998-10-05       Impact factor: 14.307
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