D M Eisenstein1, M R O'Gorman, L M Pachman. 1. Department of Pediatric Immunology and Rheumatology, Northwestern University Medical School, Chicago, IL 60614, USA.
Abstract
OBJECTIVE: To investigate whether changes in peripheral blood lymphocytes correlate with changes in disease activity in juvenile dermatomyositis (JDM). METHODS: Clinical changes in disease expression measured by a disease activity score were correlated with changes in percentages of peripheral blood lymphocyte subsets. RESULTS: Changes in the percentage of peripheral blood CD19 positive lymphocytes (B cells) correlated with changes in disease activity (Spearman rank coefficients = 0.47, p = 0.02). There were no significant correlations in disease activity with changes of T cell subsets or the T cell activation markers CD25 or DR. CONCLUSION: Change in the percentage of peripheral blood B cells correlates with change in disease activity in patients with JDM. This variable may be of use as an indicator of immunologic activity and response to therapy.
OBJECTIVE: To investigate whether changes in peripheral blood lymphocytes correlate with changes in disease activity in juvenile dermatomyositis (JDM). METHODS: Clinical changes in disease expression measured by a disease activity score were correlated with changes in percentages of peripheral blood lymphocyte subsets. RESULTS: Changes in the percentage of peripheral blood CD19 positive lymphocytes (B cells) correlated with changes in disease activity (Spearman rank coefficients = 0.47, p = 0.02). There were no significant correlations in disease activity with changes of T cell subsets or the T cell activation markers CD25 or DR. CONCLUSION: Change in the percentage of peripheral blood B cells correlates with change in disease activity in patients with JDM. This variable may be of use as an indicator of immunologic activity and response to therapy.
Authors: M Aleksza; A Szegedi; P Antal-Szalmás; B Irinyi; L Gergely; A Ponyi; J Hunyadi; S Sipka; M Zeher; G Szegedi; K Dankó Journal: Ann Rheum Dis Date: 2005-04-13 Impact factor: 19.103
Authors: Dong Xue Wang; Xin Lu; Ning Zu; Bing Lin; Li Ying Wang; Xiao Ming Shu; Li Ma; Guo Chun Wang Journal: Clin Rheumatol Date: 2012-08-30 Impact factor: 2.980
Authors: K Mizuno; A Yachie; S Nagaoki; H Wada; K Okada; M Kawachi; T Toma; A Konno; K Ohta; Y Kasahara; S Koizumi Journal: Clin Exp Immunol Date: 2004-07 Impact factor: 4.330
Authors: Christopher J M Piper; Meredyth G Ll Wilkinson; Claire T Deakin; Georg W Otto; Stefanie Dowle; Chantal L Duurland; Stuart Adams; Emiliano Marasco; Elizabeth C Rosser; Anna Radziszewska; Rita Carsetti; Yiannis Ioannou; Philip L Beales; Daniel Kelberman; David A Isenberg; Claudia Mauri; Kiran Nistala; Lucy R Wedderburn Journal: Front Immunol Date: 2018-06-22 Impact factor: 7.561