Literature DB >> 9291681

DNA vaccines for malaria: the past, the present, & the future.

D L Doolan1, R C Hedstrom, R Wang, M Sedegah, L F Scheller, P Hobart, J A Norman, S L Hoffman.   

Abstract

The first clinical trial of a DNA vaccine designed to protect against malaria has just commenced. This vaccine has been designed to induce protective CD8+ T cell responses against Plasmodium falciparum infected hepatocytes. Herein, we review the rationale behind the development of vaccines that induce protective CD8+ T cells, the strategy for the development of a DNA vaccine designed to protect against falciparum malaria, and the experimental data in rodent models and nonhuman primates which has provided the foundation for trials of DNA vaccines against P. falciparum malaria in humans.

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Year:  1997        PMID： 9291681

Source DB:  PubMed          Journal:  Indian J Med Res        ISSN： 0971-5916            Impact factor:   2.375


  3 in total

1.  Future use-cases of vaccines in malaria control and elimination.

Authors:  Melissa A Penny; Flavia Camponovo; Nakul Chitnis; Thomas A Smith; Marcel Tanner
Journal:  Parasite Epidemiol Control       Date:  2020-05-06

2.  Repeated clinical malaria episodes are associated with modification of the immune system in children.

Authors:  Yaw Bediako; Rhys Adams; Adam J Reid; John Joseph Valletta; Francis M Ndungu; Jan Sodenkamp; Jedidah Mwacharo; Joyce Mwongeli Ngoi; Domtila Kimani; Oscar Kai; Juliana Wambua; George Nyangweso; Etienne P de Villiers; Mandy Sanders; Magda Ewa Lotkowska; Jing-Wen Lin; Sarah Manni; John W G Addy; Mario Recker; Chris Newbold; Matthew Berriman; Philip Bejon; Kevin Marsh; Jean Langhorne
Journal:  BMC Med       Date:  2019-03-13       Impact factor: 8.775

3.  Protective CD8+ T-cell immunity to human malaria induced by chimpanzee adenovirus-MVA immunisation.

Authors:  Katie J Ewer; Geraldine A O'Hara; Christopher J A Duncan; Katharine A Collins; Susanne H Sheehy; Arturo Reyes-Sandoval; Anna L Goodman; Nick J Edwards; Sean C Elias; Fenella D Halstead; Rhea J Longley; Rosalind Rowland; Ian D Poulton; Simon J Draper; Andrew M Blagborough; Eleanor Berrie; Sarah Moyle; Nicola Williams; Loredana Siani; Antonella Folgori; Stefano Colloca; Robert E Sinden; Alison M Lawrie; Riccardo Cortese; Sarah C Gilbert; Alfredo Nicosia; Adrian V S Hill
Journal:  Nat Commun       Date:  2013       Impact factor: 14.919
  3 in total

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