BACKGROUND: Isolated thrombosis of the deep cerebral venous system is very rare and is associated with a poor prognosis. Antithrombin III (AT III) deficiency is a disorder of hypercoagulability associated with deep venous thrombosis and recurrent pulmonary emboli. We report a case of an 18-year-old man who presented with spontaneous thrombosis of the deep cerebral veins and straight dural sinus as the initial presentation of a previously undiagnosed AT III deficiency. METHODS: The patient was managed using direct endovascular infusion of the fibrinolytic agent urokinase followed by intravenous heparin. RESULTS: The technique was successful in establishing patency of the deep cerebral venous system. The patient experienced a good clinical outcome. CONCLUSIONS: Direct endovascular thrombolysis is a potentially effective management strategy for isolated thrombosis of the deep cerebral venous system.
BACKGROUND: Isolated thrombosis of the deep cerebral venous system is very rare and is associated with a poor prognosis. Antithrombin III(AT III) deficiency is a disorder of hypercoagulability associated with deep venous thrombosis and recurrent pulmonary emboli. We report a case of an 18-year-old man who presented with spontaneous thrombosis of the deep cerebral veins and straight dural sinus as the initial presentation of a previously undiagnosed AT III deficiency. METHODS: The patient was managed using direct endovascular infusion of the fibrinolytic agent urokinase followed by intravenous heparin. RESULTS: The technique was successful in establishing patency of the deep cerebral venous system. The patient experienced a good clinical outcome. CONCLUSIONS: Direct endovascular thrombolysis is a potentially effective management strategy for isolated thrombosis of the deep cerebral venous system.
Authors: Leonard Ll Yeo; Priscillia Ps Lye; Kong Wan Yee; Yang Cunli; Tu Tian Ming; Andrew Fw Ho; Vijay K Sharma; Bernard Pl Chan; Benjamin Yq Tan; Anil Gopinathan Journal: Clin Neuroradiol Date: 2020-06-11 Impact factor: 3.649
Authors: Maxim Mokin; Demetrius K Lopes; Mandy J Binning; Erol Veznedaroglu; Kenneth M Liebman; Adam S Arthur; Vinodh T Doss; Elad I Levy; Adnan H Siddiqui Journal: Interv Neuroradiol Date: 2015-06-08 Impact factor: 1.610