Literature DB >> 928949

Neurochemical effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin in Wistar and Gunn rats.

E Elovaara, H Savolainen, M G Parkki, A Aitio, H Vainio.   

Abstract

Normal Wistar, heterozygous and homozygous Gunn rats were killed one week after a single intragastric dose of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), 20 microgram/kg in acetone-olive oil. Control animals were treated similarly but without TCDD. The brain protein and RNA content were measured together with enzyme assays of lysosomal acid proteinase and soluble DT-diaphorase. Acid proteinase activity was increased in the brains of the normal Wistar rats after TCDD treatment. RNA and protein contents were lowered in the heterozygous Gunn rats whereas no changes were detected in the homozygous Gunn rats. The cerebral soluble DT-diaphorase activity was slightly enhanced (about 35%) by TCDD treatment only in normal Wistar rats. Our results may point at modified neurotoxic effects of TCDD in chronic exposure to bilirubin as in the case of Gunn rats.

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Year:  1977        PMID： 928949

Source DB:  PubMed          Journal:  Res Commun Chem Pathol Pharmacol        ISSN： 0034-5164


  10 in total

1.  Pulmonary toxicity of inhaled styrene in acetone-, phenobarbital- and 3-methylcholanthrene-treated rats.

Authors:  E Elovaara; H Vainio; A Aitio
Journal:  Arch Toxicol       Date:  1990       Impact factor: 5.153

2.  Neurochemical effects on rats of n-heptane inhalation exposure.

Authors:  H Savolainen; P Pfäffli
Journal:  Arch Environ Contam Toxicol       Date:  1980       Impact factor: 2.804

3.  Dose-dependent neurochemical changes during short-term inhalation exposure to m-xylene.

Authors:  H Savolainen; P Pfäffli
Journal:  Arch Toxicol       Date:  1980-07       Impact factor: 5.153

4.  Neurochemical effects of short-term inhalation exposure to vinyltoluene vapor.

Authors:  H Savolainen; P Pfäffli
Journal:  Arch Environ Contam Toxicol       Date:  1981-07       Impact factor: 2.804

5.  Biochemical and toxicological effects of short-term, intermittent xylene inhalation exposure and combined ethanol intake.

Authors:  H Savolainen; H Vainio; M Helojoki; E Elovaara
Journal:  Arch Toxicol       Date:  1978-12-28       Impact factor: 5.153

6.  Effects of commercial chlorophenolate, 2,3,7,8-TCDD, and pure phenoxyacetic acids on hepatic peroxisome proliferation, xenobiotic metabolism and sister chromatid exchange in the rat.

Authors:  R Mustonen; E Elovaara; A Zitting; K Linnainmaa; H Vainio
Journal:  Arch Toxicol       Date:  1989       Impact factor: 5.153

7.  Toxicity of polymethylmethacrylate thermodegradation products.

Authors:  S Vainiotalo; A Zitting; S Jacobsson; J Nickels; H Koskinen; H Savolainen
Journal:  Arch Toxicol       Date:  1984-07       Impact factor: 5.153

8.  Effects of single and repeated exposures to thermo-oxidative degradation products of poly(acrylonitrile-butadiene-styrene) (ABS) on rat lung, liver, kidney, and brain.

Authors:  A Zitting; H Savolainen
Journal:  Arch Toxicol       Date:  1980-12       Impact factor: 5.153

9.  Maternal drug abuse and human term placental xenobiotic and steroid metabolizing enzymes in vitro.

Authors:  P Paakki; H Stockmann; M Kantola; P Wagner; U Lauper; R Huch; E Elovaara; P Kirkinen; M Pasanen
Journal:  Environ Health Perspect       Date:  2000-02       Impact factor: 9.031

Review 10.  The Aryl Hydrocarbon Receptor and the Nervous System.

Authors:  Ludmila Juricek; Xavier Coumoul
Journal:  Int J Mol Sci       Date:  2018-08-24       Impact factor: 5.923
  10 in total

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