| Literature DB >> 9288167 |
H Miyachi1, A Azuma, A Ogasawara, E Uchimura, N Watanabe, Y Kobayashi, F Kato, M Kato, Y Hashimoto.
Abstract
Novel N-substituted phthalimides (2-substituted 1H-isoindole-1,3-diones) were prepared, and their effects on tumor necrosis factor-alpha (TNF-alpha) production by human leukemia cell line HL-60 stimulated with 12-O-tetradecanoylphorbol 13-acetate (TPA) or okadaic acid (OA) were examined. A structure-activity relationship study of the N-phenylphthalimides and N-benzylphthalimides revealed that their enhancing effect on TPA-induced TNF-alpha production by HL-60 cells and their inhibiting effect on OA-induced TNF-alpha production by HL-60 cells are only partially correlated.Entities:
Mesh：
Substances：
Year: 1997 PMID： 9288167 DOI： 10.1021/jm970109q
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446