Literature DB >> 9287121

Glutamine accelerates interleukin-6 production by rat peritoneal macrophages in culture.

A Yassad1, A Lavoinne, A Bion, M Daveau, A Husson.   

Abstract

The effect of glutamine on the production of interleukin-6 (IL-6) was studied in rat peritoneal macrophages in culture. A maximal production of IL-6 was measured at 4 h in lipopolysaccharide (LPS)-stimulated macrophages, and addition of glutamine (5 mM) anticipated this increase by 1 h without any increase in the IL-6 mRNA level. The effect of glutamine required the presence of LPS. Thus, glutamine accelerates IL-6 production from the pre-existing mRNA. The effect of glutamine was not mediated by cell swelling since culture of macrophages in hypoosmotic condition decreased the production of IL-6 in the culture medium with a corresponding decrease in the IL-6 mRNA level.

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Year:  1997        PMID： 9287121     DOI： 10.1016/s0014-5793(97)00881-8

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  5 in total

1.  Glutamine depletion potentiates leucocyte-dependent inflammatory events induced by carrageenan or Clostridium difficile toxin A in rats.

Authors:  Silvia B Nascimento; Romualdo B Sousa; Marcos Jullian B Martins; Antoniella Souza Gomes; Marcellus Henrique L P Souza; Richard L Guerrant; Fernando Q Cunha; Ronaldo A Ribeiro; Gerly A C Brito
Journal:  Immunology       Date:  2005-11       Impact factor: 7.397

2.  Modulation of the nuclear factor-kappa B (NF-κB) signalling pathway by glutamine in peritoneal macrophages of a murine model of protein malnutrition.

Authors:  Fabiana da Silva Lima; Marcelo Macedo Rogero; Mayara Caldas Ramos; Primavera Borelli; Ricardo Ambrósio Fock
Journal:  Eur J Nutr       Date:  2012-08-26       Impact factor: 5.614

3.  Peritoneal tissue-resident macrophages are metabolically poised to engage microbes using tissue-niche fuels.

Authors:  Luke C Davies; Christopher M Rice; Erika M Palmieri; Philip R Taylor; Douglas B Kuhns; Daniel W McVicar
Journal:  Nat Commun       Date:  2017-12-12       Impact factor: 14.919

4.  In vitro suppression of inflammatory cytokine response by methionine sulfoximine.

Authors:  Tyler J Peters; Amruta A Jambekar; William S A Brusilow
Journal:  J Inflamm (Lond)       Date:  2018-09-10       Impact factor: 4.981

5.  Targeting Glycolysis in Macrophages Confers Protection Against Pancreatic Ductal Adenocarcinoma.

Authors:  Hweixian Leong Penny; Je Lin Sieow; Sin Yee Gun; Mai Chan Lau; Bernett Lee; Jasmine Tan; Cindy Phua; Florida Toh; Yvonne Nga; Wei Hseun Yeap; Baptiste Janela; Dilip Kumar; Hao Chen; Joe Yeong; Justin A Kenkel; Angela Pang; Diana Lim; Han Chong Toh; Tony Lim Kiat Hon; Christopher I Johnson; Hanif Javanmard Khameneh; Alessandra Mortellaro; Edgar G Engleman; Olaf Rotzschke; Florent Ginhoux; Jean-Pierre Abastado; Jinmiao Chen; Siew Cheng Wong
Journal:  Int J Mol Sci       Date:  2021-06-14       Impact factor: 5.923
  5 in total

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