Literature DB >> 9286244

Mitogenic properties of human gastric juice.

H Kataoka1, T Joh, K Kasugai, T Kato, A Moriyama.   

Abstract

This study was performed to define the biologically active growth modulators in human gastric juice. Mitogenic activity was evaluated by the incorporation of [3H]thymidine into 3T3 fibroblasts. A negative correlation was observed between pH and mitogenic activity in gastric juice (r = -0.45, P < 0.01). The concentrations of epidermal growth factor (EGF), transforming growth factor-alpha and -beta 1 (TGF-alpha and -beta 1), platelet-derived growth factor (PDGF), and basic fibroblast growth factor (bFGF) in gastric juice did not explain these changes in mitogenic activity. Gel filtration identified growth-stimulating activity due to small molecule mitogens (less than 13 kDa), and growth inhibitory activity only in neutral samples due to a macromolecular substance (larger than 240 kDa) susceptible to trypsin digestion and heat and acid treatments. We conclude that acidity-dependent changes in mitogenic activity observed in this study are due to appearance of acid-unstable, high-molecular-weight, growth-inhibitory substance.

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Year:  1997        PMID： 9286244     DOI： 10.1023/a:1018877918894

Source DB:  PubMed          Journal:  Dig Dis Sci        ISSN： 0163-2116            Impact factor:   3.199


  23 in total

Review 1.  Peptides and gastrointestinal mucosal integrity.

Authors:  R J Playford
Journal:  Gut       Date:  1995-11       Impact factor: 23.059

2.  Effect of epidermal growth factor in combination with sucralfate or omeprazole on the healing of chronic gastric ulcers in the rat.

Authors:  M Itoh; S Imai; T Joh; Y Yokoyama; N Yasue; A Iwai; K Matsusako; K Endoh; T Kawai; T Takeuchi
Journal:  J Clin Gastroenterol       Date:  1990       Impact factor: 3.062

3.  Effect of salivary epidermal growth factor on wound healing of tongue in mice.

Authors:  S Noguchi; Y Ohba; T Oka
Journal:  Am J Physiol       Date:  1991-04

4.  Distribution and release of epidermal growth factor in man.

Authors:  J W Konturek; W Bielanski; S J Konturek; J Bogdal; J Oleksy
Journal:  Gut       Date:  1989-09       Impact factor: 23.059

5.  Epidermal growth factor is digested to smaller, less active forms in acidic gastric juice.

Authors:  R J Playford; T Marchbank; D P Calnan; J Calam; P Royston; J J Batten; H F Hansen
Journal:  Gastroenterology       Date:  1995-01       Impact factor: 22.682

6.  Physiological concentrations of human epidermal growth factor in biological fluids: use of a sensitive enzyme immunoassay.

Authors:  T Joh; M Itoh; K Katsumi; Y Yokoyama; T Takeuchi; T Kato; Y Wada; R Tanaka
Journal:  Clin Chim Acta       Date:  1986-07-15       Impact factor: 3.786

7.  Effect of luminal growth factor preservation on intestinal growth.

Authors:  R J Playford; A C Woodman; P Clark; P Watanapa; D Vesey; P H Deprez; R C Williamson; J Calam
Journal:  Lancet       Date:  1993-04-03       Impact factor: 79.321

8.  Accelerated healing of duodenal ulcers by oral administration of a mutein of basic fibroblast growth factor in rats.

Authors:  S Szabo; J Folkman; P Vattay; R E Morales; G S Pinkus; K Kato
Journal:  Gastroenterology       Date:  1994-04       Impact factor: 22.682

9.  Nerve growth factor: acceleration of the rate of wound healing in mice.

Authors:  A K Li; M J Koroly; M E Schattenkerk; R A Malt; M Young
Journal:  Proc Natl Acad Sci U S A       Date:  1980-07       Impact factor: 11.205

10.  A sensitive enzyme immunoassay system of rat epidermal growth factor in biological fluids and tissue extracts.

Authors:  T Joh; M Itoh; N Yasue; T Miyamoto; A Iwai; K Matsusako; K Endoh; T Takeuchi; A Moriyama; T Kato
Journal:  Acta Endocrinol (Copenh)       Date:  1989-05
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  2 in total

1.  Human transforming growth factor alpha (TGF-alpha) is digested to a smaller (1-43), less biologically active, form in acidic gastric juice.

Authors:  T Marchbank; R Boulton; H Hansen; R J Playford
Journal:  Gut       Date:  2002-12       Impact factor: 23.059

2.  Increased p53 expression in the malignant transformation of Barrett's esophagus is accompanied by an upward shift of the proliferative compartment.

Authors:  Istvan Hritz; Hajnalka Gyorffy; Bela Molnar; Gabor Lakatos; Ferenc Sipos; Istvan Pregun; Mark Juhasz; Laszlo Pronai; Zsuzsa Schaff; Zsolt Tulassay; Laszlo Herszenyi
Journal:  Pathol Oncol Res       Date:  2008-08-28       Impact factor: 3.201
  2 in total

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