Literature DB >> 9285689

Differential expression patterns of the PEA3 group transcription factors through murine embryonic development.

A Chotteau-Lelièvre1, X Desbiens, H Pelczar, P A Defossez, Y de Launoit.   

Abstract

ERM, ER81 and PEA3 are three highly related transcription factors belonging to the ETS family. Together they form the PEA3 group within this family. Little data is yet available regarding the roles of these three genes during embryonic development. A prerequisite to investigations in this field is to obtain an accurate spatio-temporal expression map for the erm, er81 and pea3 genes. To this end, we have used in situ hybridization to compare their expression patterns during critical stages of murine embryogenesis. We report that all three genes are expressed in numerous developing organs coming from different embryonic tissues. The three genes appeared co-expressed in different organs but presented specific sites of expression, so that the resultant expression pattern could in fact reveal several distinct functions depending upon isolated and/or various combinations of the PEA3 member expression. These results suggest that erm, er81 and pea3 genes are differentially regulated, probably to serve important functions as cell proliferation control, tissue interaction mediator or cell differentiation, all over successive steps of the mouse organogenesis.

Entities:  

Mesh:

Substances:

Year:  1997        PMID: 9285689     DOI: 10.1038/sj.onc.1201261

Source DB:  PubMed          Journal:  Oncogene        ISSN: 0950-9232            Impact factor:   9.867


  39 in total

1.  Male sexual dysfunction in mice bearing targeted mutant alleles of the PEA3 ets gene.

Authors:  M A Laing; S Coonrod; B T Hinton; J W Downie; R Tozer; M A Rudnicki; J A Hassell
Journal:  Mol Cell Biol       Date:  2000-12       Impact factor: 4.272

Review 2.  Function of PEA3 Ets transcription factors in mammary gland development and oncogenesis.

Authors:  Natasza A Kurpios; Nancy A Sabolic; Trevor G Shepherd; Gina M Fidalgo; John A Hassell
Journal:  J Mammary Gland Biol Neoplasia       Date:  2003-04       Impact factor: 2.673

3.  Regulation of c-Maf and αA-Crystallin in Ocular Lens by Fibroblast Growth Factor Signaling.

Authors:  Qing Xie; Rebecca McGreal; Raven Harris; Chun Y Gao; Wei Liu; Lixing W Reneker; Linda S Musil; Ales Cvekl
Journal:  J Biol Chem       Date:  2015-12-30       Impact factor: 5.157

4.  p38 MAP kinase inhibition enables proliferation of adult mammalian cardiomyocytes.

Authors:  Felix B Engel; Michael Schebesta; Mychelle T Duong; Gang Lu; Shuxun Ren; Jeffery B Madwed; Huiping Jiang; Yibin Wang; Mark T Keating
Journal:  Genes Dev       Date:  2005-05-03       Impact factor: 11.361

Review 5.  Mechanistic insights into the regulation of the spermatogonial stem cell niche.

Authors:  Rex A Hess; Paul S Cooke; Marie-Claude Hofmann; Kenneth M Murphy
Journal:  Cell Cycle       Date:  2006-06-01       Impact factor: 4.534

Review 6.  Signaling and Gene Regulatory Networks in Mammalian Lens Development.

Authors:  Ales Cvekl; Xin Zhang
Journal:  Trends Genet       Date:  2017-08-31       Impact factor: 11.639

7.  PEA3 is necessary for optimal epidermal growth factor receptor-stimulated matrix metalloproteinase expression and invasion of ovarian tumor cells.

Authors:  Karen D Cowden Dahl; Reema Zeineldin; Laurie G Hudson
Journal:  Mol Cancer Res       Date:  2007-05-02       Impact factor: 5.852

8.  ERM is required for transcriptional control of the spermatogonial stem cell niche.

Authors:  Chen Chen; Wenjun Ouyang; Vadim Grigura; Qing Zhou; Kay Carnes; Hyunjung Lim; Guang-Quan Zhao; Silvia Arber; Natasza Kurpios; Theresa L Murphy; Alec M Cheng; John A Hassell; Varadaraj Chandrashekar; Marie-Claude Hofmann; Rex A Hess; Kenneth M Murphy
Journal:  Nature       Date:  2005-08-18       Impact factor: 49.962

9.  DMRT5, DMRT3, and EMX2 Cooperatively Repress Gsx2 at the Pallium-Subpallium Boundary to Maintain Cortical Identity in Dorsal Telencephalic Progenitors.

Authors:  Elodie Desmaris; Marc Keruzore; Amandine Saulnier; Leslie Ratié; Stavroula Assimacopoulos; Sarah De Clercq; Xinsheng Nan; Kaushik Roychoudhury; Shenyue Qin; Sadia Kricha; Clément Chevalier; Thomas Lingner; Kristine A Henningfeld; David Zarkower; Antonello Mallamaci; Thomas Theil; Kenneth Campbell; Tomas Pieler; Meng Li; Elizabeth A Grove; Eric J Bellefroid
Journal:  J Neurosci       Date:  2018-08-24       Impact factor: 6.167

10.  Pea3 transcription factors and wnt1-induced mouse mammary neoplasia.

Authors:  Rebecca Baker; Claire V Kent; Rachel A Silbermann; John A Hassell; Lawrence J T Young; Louise R Howe
Journal:  PLoS One       Date:  2010-01-22       Impact factor: 3.240

View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.