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Literature DB >> 9285082

Anxiogenic effects of high illumination levels assessed with the acoustic startle response in rats.

Abstract

Previous studies have shown that the amplitude of the acoustic startle reflex is increased by the presentation of aversive stimuli. In the present study, the amplitude of acoustic startle in rats was increased by exposure to high illumination levels. The effect was directly related to the intensity (0, 8, 70, and 700 footlamberts) of illumination (experiment I); was blocked by the anxiolytic compound buspirone (experiment II); and showed little or no habituation with repeated testing (experiment III). These results suggest that the elevation of startle amplitude by light may reflect an unconditioned anxiogenic effect of high illumination levels. The possible utility of this phenomenon as an animal model of anxiety is discussed.

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Year: 1997 PMID： 9285082 DOI： 10.1016/S0006-3223(96)00441-6

Source DB: PubMed Journal: Biol Psychiatry ISSN： 0006-3223 Impact factor: 13.382

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Cited

57 in total

1. Anxiolytic effects of a novel group II metabotropic glutamate receptor agonist (LY354740) in the fear-potentiated startle paradigm in humans.

Authors: Christian Grillon; Jeremy Cordova; Louise R Levine; Charles A Morgan
Journal: Psychopharmacology (Berl) Date: 2003-04-23 Impact factor: 4.530

2. Reduction of fear-potentiated startle by benzodiazepines in C57BL/6J mice.

Authors: Kiersten S Smith; Edward G Meloni; Karyn M Myers; Ashlee Van't Veer; William A Carlezon; Uwe Rudolph
Journal: Psychopharmacology (Berl) Date: 2010-10-05 Impact factor: 4.530

3. Alcohol stress response dampening: selective reduction of anxiety in the face of uncertain threat.

Authors: Kathryn R Hefner; John J Curtin
Journal: J Psychopharmacol Date: 2011-09-21 Impact factor: 4.153

4. Mood disorder susceptibility gene CACNA1C modifies mood-related behaviors in mice and interacts with sex to influence behavior in mice and diagnosis in humans.

Authors: David T Dao; Pamela Belmonte Mahon; Xiang Cai; Colleen E Kovacsics; Robert A Blackwell; Michal Arad; Jianxin Shi; Peter P Zandi; Patricio O'Donnell; James A Knowles; Myrna M Weissman; William Coryell; William A Scheftner; William B Lawson; Douglas F Levinson; Scott M Thompson; James B Potash; Todd D Gould
Journal: Biol Psychiatry Date: 2010-08-17 Impact factor: 13.382

10. Chronic stress increases pituitary adenylate cyclase-activating peptide (PACAP) and brain-derived neurotrophic factor (BDNF) mRNA expression in the bed nucleus of the stria terminalis (BNST): roles for PACAP in anxiety-like behavior.

Authors: Sayamwong E Hammack; Joseph Cheung; Kimberly M Rhodes; Kristin C Schutz; William A Falls; Karen M Braas; Victor May
Journal: Psychoneuroendocrinology Date: 2009-01-31 Impact factor: 4.905

Anxiogenic effects of high illumination levels assessed with the acoustic startle response in rats.

1. Anxiolytic effects of a novel group II metabotropic glutamate receptor agonist (LY354740) in the fear-potentiated startle paradigm in humans.

2. Reduction of fear-potentiated startle by benzodiazepines in C57BL/6J mice.

3. Alcohol stress response dampening: selective reduction of anxiety in the face of uncertain threat.

4. Mood disorder susceptibility gene CACNA1C modifies mood-related behaviors in mice and interacts with sex to influence behavior in mice and diagnosis in humans.

5. The brain orexin system and almorexant in fear-conditioned startle reactions in the rat.

6. Alcohol stress response dampening during imminent versus distal, uncertain threat.

Review 7. Interaction between startle and voluntary reactions in humans.

Review 8. Developmental rodent models of fear and anxiety: from neurobiology to pharmacology.

9. Affective and somatic aspects of spontaneous and precipitated nicotine withdrawal in C57BL/6J and BALB/cByJ mice.

10. Chronic stress increases pituitary adenylate cyclase-activating peptide (PACAP) and brain-derived neurotrophic factor (BDNF) mRNA expression in the bed nucleus of the stria terminalis (BNST): roles for PACAP in anxiety-like behavior.