Literature DB >> 9284182

A human monoclonal antibody which inhibits the coaggregation activity of Porphyromonas gingivalis.

Y Abiko1, N Ogura, U Matsuda, K Yanagi, H Takiguchi.   

Abstract

A B-cell line producing a human monoclonal antibody (HuMAb) against a recombinant 40-kDa outer membrane protein (OMP) of Porphyromonas gingivalis was constructed by in vivo immunization of a severe combined immunodeficiency C.B.-17/Icr mouse, which had been injected with human peripheral blood lymphocytes, with recombinant 40-kDa OMP and subsequent Epstein-Barr virus immortalization of B cells isolated from the spleen of the mouse. This HuMAb inhibited coaggregation between P. gingivalis vesicles and Actinomyces naeslundii cells.

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Year:  1997        PMID： 9284182      PMCID： PMC175569          DOI： 10.1128/iai.65.9.3966-3969.1997

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  24 in total

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5.  Epstein-Barr virus receptor of human B lymphocytes is the C3d receptor CR2.

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