Literature DB >> 9283

Amino-acid sequence of a coelenterate toxin: toxin II from Anemonia sulcata.

G Wunderer, H Fritz, E Wachter, W Machleidt.   

Abstract

Toxin II from Anemonia sulcata, the main component of the sea anemone venom, consists of 47 amino acid residues which are interconnected by three disulfide bridges. The S-aminoethylated polypeptide was coupled to activated glass beads and sequenced to position 33 by automated solid-phase Edman degradation. Blanks arising from anchor points and the rest of the sequence were determined from tryptic peptides of the [14C]carboxymethylated toxin. Toxin II shows no significant homologies with other known sequences of neurotoxins or cardiotoxins. It might constitute a new class of polypeptide toxins.

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Year:  1976        PMID： 9283     DOI： 10.1111/j.1432-1033.1976.tb10778.x

Source DB:  PubMed          Journal:  Eur J Biochem        ISSN： 0014-2956


  10 in total

1.  Characterization of two Bunodosoma granulifera toxins active on cardiac sodium channels.

Authors:  C Goudet; T Ferrer; L Galàn; A Artiles; C F Batista; L D Possani; J Alvarez; A Aneiros; J Tytgat
Journal:  Br J Pharmacol       Date:  2001-11       Impact factor: 8.739

Review 2.  Sea anemone toxins affecting voltage-gated sodium channels--molecular and evolutionary features.

Authors:  Yehu Moran; Dalia Gordon; Michael Gurevitz
Journal:  Toxicon       Date:  2009-03-05       Impact factor: 3.033

3.  Mechanical and electrophysiological effects of sea anemone (Anemonia sulcata) toxins on rat innervated and denervated skeletal muscle.

Authors:  C Alsen; J B Harris; I Tesseraux
Journal:  Br J Pharmacol       Date:  1981-09       Impact factor: 8.739

4.  Binding of sea anemone toxin to receptor sites associated with gating system of sodium channel in synaptic nerve endings in vitro.

Authors:  J P Vincent; M Balerna; J Barhanin; M Fosset; M Lazdunski
Journal:  Proc Natl Acad Sci U S A       Date:  1980-03       Impact factor: 11.205

5.  Iodine labelling of sea anemone toxin II, and binding to normal and denervated diaphragm.

Authors:  E Habermann; L Beress
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1979-11       Impact factor: 3.000

6.  CgNa, a type I toxin from the giant Caribbean sea anemone Condylactis gigantea shows structural similarities to both type I and II toxins, as well as distinctive structural and functional properties(1).

Authors:  Emilio Salceda; Javier Pérez-Castells; Blanca López-Méndez; Anoland Garateix; Hector Salazar; Omar López; Abel Aneiros; Ludger Ständker; Lászlo Béress; Wolf-Georg Forssmann; Enrique Soto; Jesús Jiménez-Barbero; Guillermo Giménez-Gallego
Journal:  Biochem J       Date:  2007-08-15       Impact factor: 3.857

Review 7.  Peptide toxins in sea anemones: structural and functional aspects.

Authors:  Tomohiro Honma; Kazuo Shiomi
Journal:  Mar Biotechnol (NY)       Date:  2006-01-01       Impact factor: 3.619

Review 8.  Voltage-Gated Sodium Channels: A Prominent Target of Marine Toxins.

Authors:  Rawan Mackieh; Rita Abou-Nader; Rim Wehbe; César Mattei; Christian Legros; Ziad Fajloun; Jean Marc Sabatier
Journal:  Mar Drugs       Date:  2021-10-05       Impact factor: 5.118

9.  Digital marine bioprospecting: mining new neurotoxin drug candidates from the transcriptomes of cold-water sea anemones.

Authors:  Ilona Urbarova; Bård Ove Karlsen; Siri Okkenhaug; Ole Morten Seternes; Steinar D Johansen; Åse Emblem
Journal:  Mar Drugs       Date:  2012-10-18       Impact factor: 6.085

Review 10.  The Anemonia viridis Venom: Coupling Biochemical Purification and RNA-Seq for Translational Research.

Authors:  Aldo Nicosia; Alexander Mikov; Matteo Cammarata; Paolo Colombo; Yaroslav Andreev; Sergey Kozlov; Angela Cuttitta
Journal:  Mar Drugs       Date:  2018-10-25       Impact factor: 5.118
  10 in total

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