| Literature DB >> 9282856 |
M A van Buchem1, J K Udupa, J C McGowan, Y Miki, F H Heyning, M P Boncoeur-Martel, D L Kolson, M Polansky, R I Grossman.
Abstract
We report a semiautomated postprocessing method based on magnetization transfer MR imaging that can quantify the extent of global disease in patients with multiple sclerosis. The technique combines segmentation and quantitative analysis of imaging data reflecting the structural integrity of white matter. Applications of this technique may include assessment of disease progress and of the efficacy of experimental therapeutic intervention. The height of the histogram peak corresponding to white matter was found to be lowered in patients with multiple sclerosis and the overall distribution of magnetization transfer ratios was shifted to lower values.Entities:
Mesh:
Year: 1997 PMID: 9282856 PMCID: PMC8338026
Source DB: PubMed Journal: AJNR Am J Neuroradiol ISSN: 0195-6108 Impact factor: 3.825