OBJECTIVE: Evaluation of the effectiveness of periodontal treatments on cyclosporine-induced gingival overgrowth. DESIGN:Longitudinal study between months 6 and 12 after transplant, in 80 cyclosporine-treated heart, liver and kidney transplant patients. SETTING: Madrid Puerta de Hierro Hospital. SUBJECTS AND METHODS: The 37 patients who had developed overgrowth in the sixth month were randomly split into three study groups. The remaining 43 were split into two additional groups. INTERVENTIONS: The first group underwent professional cleaning; the second underwent, additionally, scaling and root planing, and the third group received no treatment. The fourth and the fifth groups received no treatment and professional cleaning, respectively. MAIN OUTCOME MEASURES: O'Leary plaque index, Lenox and Kopczyk gingival index, and average gingival overgrowth. RESULTS: A significant (P = 0.008) increase in overgrowth was found in the third group that did not undergo treatment. Significantly (P = 0.002) less was found in the first and second groups. Highly significant (P = 0.001) reductions in the plaque and gingivitis indices were also found in these two groups. The fifth group showed a highly significant (P = 0.0001) decrease in the plaque and gingivitis indices. CONCLUSIONS:Professional cleaning is effective in reducing both gingivitis and cyclosporine-induced gingival overgrowth; the combination with scaling and root planing reinforces its effectiveness.
RCT Entities:
OBJECTIVE: Evaluation of the effectiveness of periodontal treatments on cyclosporine-induced gingival overgrowth. DESIGN: Longitudinal study between months 6 and 12 after transplant, in 80 cyclosporine-treated heart, liver and kidney transplant patients. SETTING: Madrid Puerta de Hierro Hospital. SUBJECTS AND METHODS: The 37 patients who had developed overgrowth in the sixth month were randomly split into three study groups. The remaining 43 were split into two additional groups. INTERVENTIONS: The first group underwent professional cleaning; the second underwent, additionally, scaling and root planing, and the third group received no treatment. The fourth and the fifth groups received no treatment and professional cleaning, respectively. MAIN OUTCOME MEASURES: O'Leary plaque index, Lenox and Kopczyk gingival index, and average gingival overgrowth. RESULTS: A significant (P = 0.008) increase in overgrowth was found in the third group that did not undergo treatment. Significantly (P = 0.002) less was found in the first and second groups. Highly significant (P = 0.001) reductions in the plaque and gingivitis indices were also found in these two groups. The fifth group showed a highly significant (P = 0.0001) decrease in the plaque and gingivitis indices. CONCLUSIONS: Professional cleaning is effective in reducing both gingivitis and cyclosporine-induced gingival overgrowth; the combination with scaling and root planing reinforces its effectiveness.