Literature DB >> 9280292

Glycoprotein VI is the collagen receptor in platelets which underlies tyrosine phosphorylation of the Fc receptor gamma-chain.

J M Gibbins1, M Okuma, R Farndale, M Barnes, S P Watson.   

Abstract

We have recently shown that collagen activates platelets through a pathway dependent on the Fc receptor gamma-chain and the tyrosine kinase Syk. We report here that the Fc receptor gamma-chain and the candidate collagen receptor glycoprotein VI (GPVI) co-associate. Furthermore, cross-linking GPVI stimulates a similar pattern of tyrosine phosphorylation to that stimulated by collagen, including tyrosine phosphorylation of Fc receptor gamma-chain. These results support a model where GPVI couples collagen-stimulation of platelets to phosphorylation of the Fc receptor gamma-chain leading to activation of Syk and phospholipase Cgamma2.

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Year:  1997        PMID： 9280292     DOI： 10.1016/s0014-5793(97)00926-5

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  53 in total

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9.  The heptapeptide LSARLAF mediates platelet activation through phospholipase Cgamma2 independently of glycoprotein IIb-IIIa.

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10.  Inflammation drives thrombosis after Salmonella infection via CLEC-2 on platelets.

Authors:  Jessica R Hitchcock; Charlotte N Cook; Saeeda Bobat; Ewan A Ross; Adriana Flores-Langarica; Kate L Lowe; Mahmood Khan; C Coral Dominguez-Medina; Sian Lax; Manuela Carvalho-Gaspar; Stefan Hubscher; G Ed Rainger; Mark Cobbold; Christopher D Buckley; Tim J Mitchell; Andrea Mitchell; Nick D Jones; N Van Rooijen; Daniel Kirchhofer; Ian R Henderson; David H Adams; Steve P Watson; Adam F Cunningham
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