F M Cheung1, W C Wu, C K Lam, Y K Fu. 1. Department of Clinical Pathology, Pamela Youde Nethersole Eastern Hospital, Chai Wan, Hong Kong.
Abstract
AIMS: Osteoblastoma is a rare bone tumour and differentiation from osteosarcoma is occasionally a diagnostic problem. The difficulty is further compounded when such a lesion microscopically shows cytological or architectural atypia. METHODS AND RESULTS: A case of pseudomalignant osteoblastoma occurring in the left iliac crest of a 34-year-old Chinese woman is presented. Radiographic findings were non-diagnostic, but favoured a benign yet locally aggressive lesion. Histologically the diagnosis was based on the findings of classical osteoblastoma areas harbouring pseudomalignant osteoblasts in the absence of mitoses, but there were co-existing atypical architectural features also. CONCLUSION: The significance and pathogenesis of the 'permeative pattern' are discussed. Difficulties in differentiating borderline lesions are emphasized.
AIMS: Osteoblastoma is a rare bone tumour and differentiation from osteosarcoma is occasionally a diagnostic problem. The difficulty is further compounded when such a lesion microscopically shows cytological or architectural atypia. METHODS AND RESULTS: A case of pseudomalignant osteoblastoma occurring in the left iliac crest of a 34-year-old Chinese woman is presented. Radiographic findings were non-diagnostic, but favoured a benign yet locally aggressive lesion. Histologically the diagnosis was based on the findings of classical osteoblastoma areas harbouring pseudomalignant osteoblasts in the absence of mitoses, but there were co-existing atypical architectural features also. CONCLUSION: The significance and pathogenesis of the 'permeative pattern' are discussed. Difficulties in differentiating borderline lesions are emphasized.
Authors: Aldona W Woźniak; Marian Tomasz Nowaczyk; Krzysztof Osmola; Wojciech Golusinski Journal: Eur Arch Otorhinolaryngol Date: 2009-12-10 Impact factor: 2.503