AIMS: To determine and compare two urinary indices of renal tubular function, N-acetyl-glucosaminidase (NAG) and beta 2-microglobulin (beta 2 M), in healthy term neonates and babies with perinatal asphyxia. METHODS: In a prospective case-control study using asphyxiated (n = 35) and normal control (n = 55) infants, urinary NAG and beta 2 M were assayed at 24-48 hours of life, 4-6 days, and 4-6 weeks. RESULTS: NAG and beta 2 M were significantly increased at 24-48 hours and 4-6 days in the asphyxiated infants compared with the controls. Increased NAG values reflect the degree of perinatal asphyxia more than do beta 2 M. Gentamicin also increased NAG excretion, but to a lesser extent than did perinatal asphyxia. CONCLUSIONS: NAG (+/- beta 2 M) may be a useful marker of perinatal asphyxia. Urinary NAG concentrations correlate with the severity of perinatal asphyxia.
AIMS: To determine and compare two urinary indices of renal tubular function, N-acetyl-glucosaminidase (NAG) and beta 2-microglobulin (beta 2 M), in healthy term neonates and babies with perinatal asphyxia. METHODS: In a prospective case-control study using asphyxiated (n = 35) and normal control (n = 55) infants, urinary NAG and beta 2 M were assayed at 24-48 hours of life, 4-6 days, and 4-6 weeks. RESULTS:NAG and beta 2 M were significantly increased at 24-48 hours and 4-6 days in the asphyxiated infants compared with the controls. Increased NAG values reflect the degree of perinatal asphyxia more than do beta 2 M. Gentamicin also increased NAG excretion, but to a lesser extent than did perinatal asphyxia. CONCLUSIONS:NAG (+/- beta 2 M) may be a useful marker of perinatal asphyxia. Urinary NAG concentrations correlate with the severity of perinatal asphyxia.
Authors: D S Roberts; G B Haycock; R N Dalton; C Turner; P Tomlinson; L Stimmler; J W Scopes Journal: Arch Dis Child Date: 1990-10 Impact factor: 3.791
Authors: H Tsukahara; M Yoshimoto; M Saito; T Sakaguchi; I Mitsuyoshi; S Hayashi; K Nakamura; K Kikuchi; M Sudo Journal: Pediatr Nephrol Date: 1990-09 Impact factor: 3.714
Authors: Stephen J McWilliam; Daniel J Antoine; Venkata Sabbisetti; Mark A Turner; Tracey Farragher; Joseph V Bonventre; B Kevin Park; Rosalind L Smyth; Munir Pirmohamed Journal: PLoS One Date: 2012-08-24 Impact factor: 3.240