Literature DB >> 9278950

Abnormal cerebral perfusion in chronic methamphetamine abusers: a study using 99MTc-HMPAO and SPECT.

M Iyo1, H Namba, M Yanagisawa, S Hirai, N Yui, S Fukui.   

Abstract

1. Cerebral blood flow of nine methamphetamine abusers with technetium-99m-hexamethylpropyleneamine oxime (HMPAO) and single photon emission computed tomography (SPECT) as well as morphological examination with magnetic resonance imaging (MRI) were investigated. 2. Six of these subjects exhibited multiple focal perfusion deficits in cerebral cortices without abnormalities in MRI including cerebral atrophy and/or infarctions. 3. Cerebral perfusion deficits were detected in methamphetamine abusers even after a long abstinence period, suggesting that vascular changes were irreversible to some degree. 4. HMPAO SPECT study appeared to be sensitive to the detection of cerebral perfusion abnormalities in drug abusers.

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Year:  1997        PMID： 9278950     DOI： 10.1016/s0278-5846(97)00079-1

Source DB:  PubMed          Journal:  Prog Neuropsychopharmacol Biol Psychiatry        ISSN： 0278-5846            Impact factor:   5.067


  11 in total

1.  Cytochrome P450-2D6 extensive metabolizers are more vulnerable to methamphetamine-associated neurocognitive impairment: preliminary findings.

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Journal:  J Int Neuropsychol Soc       Date:  2010-08-23       Impact factor: 2.892

Review 2.  The need for speed: an update on methamphetamine addiction.

Authors:  Alasdair M Barr; William J Panenka; G William MacEwan; Allen E Thornton; Donna J Lang; William G Honer; Tania Lecomte
Journal:  J Psychiatry Neurosci       Date:  2006-09       Impact factor: 6.186

Review 3.  Neurocognitive effects of methamphetamine: a critical review and meta-analysis.

Authors:  J Cobb Scott; Steven Paul Woods; Georg E Matt; Rachel A Meyer; Robert K Heaton; J Hampton Atkinson; Igor Grant
Journal:  Neuropsychol Rev       Date:  2007-09       Impact factor: 7.444

4.  Striatal and ventral pallidum dynorphin concentrations are markedly increased in human chronic cocaine users.

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Journal:  Neuropharmacology       Date:  2008-04-29       Impact factor: 5.250

Review 5.  Neuropsychological consequences of HIV and substance abuse: a literature review and implications for treatment and future research.

Authors:  Lisa R Norman; Michael Basso; Anil Kumar; Robert Malow
Journal:  Curr Drug Abuse Rev       Date:  2009-05

6.  Methamphetamine causes sustained depression in cerebral blood flow.

Authors:  Oksana Polesskaya; Jharon Silva; Christine Sanfilippo; Taylor Desrosiers; Anita Sun; Jie Shen; Changyong Feng; Aleksey Polesskiy; Rashid Deane; Berislav Zlokovic; Karl Kasischke; Stephen Dewhurst
Journal:  Brain Res       Date:  2010-12-13       Impact factor: 3.252

7.  Amphetamine dependence and co-morbid alcohol abuse: associations to brain cortical thickness.

Authors:  Glenn Lawyer; Petr S Bjerkan; Anders Hammarberg; Nitya Jayaram-Lindström; Johan Franck; Ingrid Agartz
Journal:  BMC Pharmacol       Date:  2010-05-20

Review 8.  An Update of the Review of Neuropsychological Consequences of HIV and Substance Abuse: A Literature Review and Implications for Treatment and Future Research.

Authors:  Lisa R Norman; Michael Basso
Journal:  Curr Drug Abuse Rev       Date:  2015

9.  Fluoroethoxy-1,4-diphenethylpiperidine and piperazine derivatives: Potent and selective inhibitors of [3H]dopamine uptake at the vesicular monoamine transporter-2.

Authors:  Emily R Hankosky; Shyam R Joolakanti; Justin R Nickell; Venumadhav Janganati; Linda P Dwoskin; Peter A Crooks
Journal:  Bioorg Med Chem Lett       Date:  2017-10-20       Impact factor: 2.823

10.  1,4-Diphenalkylpiperidines: A new scaffold for the design of potent inhibitors of the vesicular monoamine transporter-2.

Authors:  Justin R Nickell; John P Culver; Venumadhav Janganati; Guangrong Zheng; Linda P Dwoskin; Peter A Crooks
Journal:  Bioorg Med Chem Lett       Date:  2016-05-10       Impact factor: 2.823
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