| Literature DB >> 9278889 |
M Lizondo1, M Pons, M Gallardo, J Estelrich.
Abstract
The physicochemical properties of enrofloxacin, a fluoroquinolone that inhibits the activity of bacterial DNA gyrase, are described. Its spectral, solubility and related physicochemical characteristics are discussed. The dissociation behaviour of enrofloxacin was examined by UV spectrophotometry at 25 degrees C in a series of buffers ranging from pH 1 to 10. The corresponding macro- and microscopic dissociation constants were calculated. The apparent n-octanol-water partition coefficients were measured from pH 2 to 10.Entities:
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Year: 1997 PMID： 9278889 DOI： 10.1016/s0731-7085(96)02033-x
Source DB: PubMed Journal: J Pharm Biomed Anal ISSN： 0731-7085 Impact factor: 3.935