Literature DB >> 9275706

Effects of steroid on diaphragmatic functions in rabbits.

M Tong1, X Kang, X Xia, S Susumu.   

Abstract

The effects of steroid on diaphragmatic contractility and endurance were examined in 24 New Zealand rabbits. Diaphragmatic contractility was determined by measuring gastric pressure (Pga) with the lower thorax and the abdomen of the animal being fixed with a rigid cast. Endurance procedure was done by continuous 15 Hz stimulation of the bilateral phrenic nerves, and diaphragmatic endurance was expressed as the time from the initiation of the endurance procedure to the moment when transdiaphragmatic pressure 15 Hz (Pdi-15 Hz) decreased to 25% of Pdimax-15 Hz. Our data suggested that intravenous administration of dexamethasone 2.5 mg daily for 7 days did not affect the diaphragmatic contractility significantly, but could cause a significant decrease in diaphragmatic endurance. When delivered intravenously at the dose of 2.0 mg daily for 14 days, dexamethasone induced a significant decrease both in diaphragmatic contractility and endurance. The recovery of the diaphragmatic strength from fatigue, however, was not influenced by dexamethasone in either circumstance. The influence of dexamethasone on diaphragmatic contractility and endurance may have important clinical implications.

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Year:  1996        PMID: 9275706     DOI: 10.1007/bf02887972

Source DB:  PubMed          Journal:  J Tongji Med Univ        ISSN: 0257-716X


  13 in total

1.  Effect of corticosteroids on diaphragm function and biochemistry in the rabbit.

Authors:  G T Ferguson; C G Irvin; R M Cherniack
Journal:  Am Rev Respir Dis       Date:  1990-01

2.  Does corticosteroid treatment affect the respiratory muscles?

Authors:  P N Dekhuijzen; G Gayan-Ramirez; M Decramer
Journal:  Eur Respir J       Date:  1993-04       Impact factor: 16.671

3.  Diaphragm fatigue induced by inspiratory resistive loading in spontaneously breathing rabbits.

Authors:  T K Aldrich; D Appel
Journal:  J Appl Physiol (1985)       Date:  1985-11

4.  Effect of corticosteroids on respiratory muscle histopathology.

Authors:  G T Ferguson; C G Irvin; R M Cherniack
Journal:  Am Rev Respir Dis       Date:  1990-11

5.  Diaphragm atrophy and weakness in cortisone-treated rats.

Authors:  B J Moore; M J Miller; H A Feldman; M B Reid
Journal:  J Appl Physiol (1985)       Date:  1989-12

6.  Corticosteroid-induced myopathy and the respiratory muscles. Report of two cases.

Authors:  S Janssens; M Decramer
Journal:  Chest       Date:  1989-05       Impact factor: 9.410

7.  Inter- and intraspecies comparisons of fibre type distribution and of succinate dehydrogenase activity in type I, IIA and IIB fibres of mammalian diaphragms.

Authors:  H J Green; H Reichmann; D Pette
Journal:  Histochemistry       Date:  1984

8.  Effects of steroids on diaphragmatic function in rats.

Authors:  N Viires; D Pavlovic; R Pariente; M Aubier
Journal:  Am Rev Respir Dis       Date:  1990-07

9.  Pathologic changes and contractile properties of the diaphragm in corticosteroid myopathy in hamsters: comparison to peripheral muscle.

Authors:  P G Wilcox; J M Hards; K Bockhold; B Bressler; R L Pardy
Journal:  Am J Respir Cell Mol Biol       Date:  1989-09       Impact factor: 6.914

10.  Disuse atrophy of skeletal muscle is associated with an increase in number of glucocorticoid receptors.

Authors:  D C DuBois; R R Almon
Journal:  Endocrinology       Date:  1980-11       Impact factor: 4.736

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