Literature DB >> 9275698

Differentiation of osteoblast in vitro is regulated by progesterone.

L Chen1, N T Foged.   

Abstract

The regulation of cellular differentiation by progesterone in fetal rat calvarial osteoblasts was investigated. Our results showed that cells cultured in the presence of progesterone had a 7% increase in the alkaline phosphatase activity when compared to untreated cells. The concentration of osteocalcin in the conditioned medium from progesterone treated osteoblasts was 28% higher than that of untreated controls. In addition, administration of progesterone significantly enhanced the number and area of bone nodules. In conclusion, progesterone stimulates the differentiation of fetal rat calvarial osteoblastic cells in vitro.

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Year:  1996        PMID： 9275698     DOI： 10.1007/bf02887963

Source DB:  PubMed          Journal:  J Tongji Med Univ        ISSN： 0257-716X


  8 in total

1.  ALP induction by beta-glycerophosphate during the non-mineralization phase in vitro.

Authors:  L Chen; J Schøller; N T Foged
Journal:  J Tongji Med Univ       Date:  1996

2.  Mineralized bone nodules formed in vitro from enzymatically released rat calvaria cell populations.

Authors:  C G Bellows; J E Aubin; J N Heersche; M E Antosz
Journal:  Calcif Tissue Int       Date:  1986-03       Impact factor: 4.333

3.  Evidence of estrogen receptors in normal human osteoblast-like cells.

Authors:  E F Eriksen; D S Colvard; N J Berg; M L Graham; K G Mann; T C Spelsberg; B L Riggs
Journal:  Science       Date:  1988-07-01       Impact factor: 47.728

4.  Stimulatory effects of estrogen and progesterone on proliferation and differentiation of normal human osteoblast-like cells in vitro.

Authors:  B A Scheven; C A Damen; N J Hamilton; H J Verhaar; S A Duursma
Journal:  Biochem Biophys Res Commun       Date:  1992-07-15       Impact factor: 3.575

5.  17 Beta-estradiol and continuous norethisterone: a unique treatment for established osteoporosis in elderly women.

Authors:  C Christiansen; B J Riis
Journal:  J Clin Endocrinol Metab       Date:  1990-10       Impact factor: 5.958

6.  Uncoupling of bone formation and resorption by combined oestrogen and progestagen therapy in postmenopausal osteoporosis.

Authors:  C Christiansen; B J Riis; L Nilas; P Rødbro; L Deftos
Journal:  Lancet       Date:  1985-10-12       Impact factor: 79.321

7.  Prevention of bone mineral loss in postmenopausal women by norethisterone.

Authors:  H I Abdalla; D M Hart; R Lindsay; I Leggate; A Hooke
Journal:  Obstet Gynecol       Date:  1985-12       Impact factor: 7.661

8.  Sex steroids and bone mass. A study of changes about the time of menopause.

Authors:  C Slemenda; S L Hui; C Longcope; C C Johnston
Journal:  J Clin Invest       Date:  1987-11       Impact factor: 14.808
  8 in total
  1 in total

1.  Induction of osteocalcin gene expression in vitro by progesterone.

Authors:  L Chen; N T Foged
Journal:  J Tongji Med Univ       Date:  1997
  1 in total

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