BACKGROUND: The present study evaluates the effects of long-term immunosuppression after cardiac transplantation on the risk for adenomatous polyps. METHODS: The endoscopic procedures performed at LDS and University Hospitals in cardiac transplant recipients were reviewed and compared with results from a previously studied control group. RESULTS: A total of 123 endoscopic procedures were performed in 98 heart transplant patients (59% for cancer screening and 41% for gastrointestinal complaints). Eighty-five percent of patients were male and 15% were female; their mean age was 57 years. In the group <3 years posttransplant, adenomatous polyps were present in 25%, hyperplastic polyps were present in 10%, and synchronous lesions in 3 patients. In the group >3 years posttransplant, adenomatous polyps were present in 16%, hyperplastic polyps were present in 22%, and synchronous lesions in were evident in 3 patients. No significant difference with results from a previously studied control group. CONCLUSIONS: Long-term immunosuppression does not increase the risk for adenomatous polyps of the colon.
BACKGROUND: The present study evaluates the effects of long-term immunosuppression after cardiac transplantation on the risk for adenomatous polyps. METHODS: The endoscopic procedures performed at LDS and University Hospitals in cardiac transplant recipients were reviewed and compared with results from a previously studied control group. RESULTS: A total of 123 endoscopic procedures were performed in 98 heart transplant patients (59% for cancer screening and 41% for gastrointestinal complaints). Eighty-five percent of patients were male and 15% were female; their mean age was 57 years. In the group <3 years posttransplant, adenomatous polyps were present in 25%, hyperplastic polyps were present in 10%, and synchronous lesions in 3 patients. In the group >3 years posttransplant, adenomatous polyps were present in 16%, hyperplastic polyps were present in 22%, and synchronous lesions in were evident in 3 patients. No significant difference with results from a previously studied control group. CONCLUSIONS: Long-term immunosuppression does not increase the risk for adenomatous polyps of the colon.
Authors: Michael Selgrad; Jan Jacob Koornstra; Lucia Fini; Marloes Blom; Rong Huang; Edward B Devol; Wytske Boersma-van Ek; Gerard Dijkstra; Robert C Verdonk; Steven de Jong; Ajay Goel; Sharenda L Williams; Richard L Meyer; Elizabeth B Haagsma; Luigi Ricciardiello; C Richard Boland Journal: Clin Cancer Res Date: 2008-10-15 Impact factor: 12.531