L Rydberg1, M Ruth, L Lundell. 1. Department of Surgery, Sahlgrenska University Hospital, University of Göteborg, Sweden.
Abstract
MAIN OBJECTIVE: There is a continuing debate whether motor abnormalities associated with gastro-oesophageal reflux disease (GORD) are primary phenomena or occur as a consequence of repeated injury caused by inflammation. To get new insights into mechanisms involved, patients were studied before and three years after effective and durable reflux control induced by two types of fundoplications. PATIENTS AND METHODS: Thirty three consecutive patients with chronic GORD entered the trial. All patients had a clinical history of GORD assessed symptomatically, endoscopically, and by use of 24 hour pH-metry. Eighteen were randomised to a 180 degrees semifundoplication (Toupet) and 15 to a total fundic wrap (Nissen-Rossetti). Manometry was done preoperatively, six months, and three years after the operation assessing motor function in defined areas of the tubular oesophagus and lower oesophageal sphincter. RESULTS: All patients had a proper control of GORD both when objectively and clinically assessed. Postoperatively, the resting tone of the lower oesophageal sphincter was significantly higher in the Nissen-Rossetti group (p < 0.05), and the intra-abdominal portion of the lower oesophageal sphincter was of identical length in the two groups. A significant increase in peristaltic amplitude in the middle and distal third of the oesophagus was recorded at long term follow up compared with the preoperative findings (p < 0.05), but there was no corresponding effect on propagation speed and duration of contraction. However, an increase in peristaltic amplitude and, as a tentative consequence, a significant decrease (p < 0.05) in the frequency of primary peristalsis was found only in patients operated on with a total fundic wrap. CONCLUSION: Despite adequate and durable reflux control after fundoplication in patients with chronic GORD, no change was found in oesophageal motor function with time. The higher contraction amplitude and decreased frequency of failed primary peristalsis seen in patients having a total fundic wrap were thus most likely due to a mechanical outflow obstruction in the gastro-oesophageal junction. These results could therefore be interpreted in favour of the hypothesis that GORD is pathogenetically linked to a primary defect in oesophageal motor function.
RCT Entities:
MAIN OBJECTIVE: There is a continuing debate whether motor abnormalities associated with gastro-oesophageal reflux disease (GORD) are primary phenomena or occur as a consequence of repeated injury caused by inflammation. To get new insights into mechanisms involved, patients were studied before and three years after effective and durable reflux control induced by two types of fundoplications. PATIENTS AND METHODS: Thirty three consecutive patients with chronic GORD entered the trial. All patients had a clinical history of GORD assessed symptomatically, endoscopically, and by use of 24 hour pH-metry. Eighteen were randomised to a 180 degrees semifundoplication (Toupet) and 15 to a total fundic wrap (Nissen-Rossetti). Manometry was done preoperatively, six months, and three years after the operation assessing motor function in defined areas of the tubular oesophagus and lower oesophageal sphincter. RESULTS: All patients had a proper control of GORD both when objectively and clinically assessed. Postoperatively, the resting tone of the lower oesophageal sphincter was significantly higher in the Nissen-Rossetti group (p < 0.05), and the intra-abdominal portion of the lower oesophageal sphincter was of identical length in the two groups. A significant increase in peristaltic amplitude in the middle and distal third of the oesophagus was recorded at long term follow up compared with the preoperative findings (p < 0.05), but there was no corresponding effect on propagation speed and duration of contraction. However, an increase in peristaltic amplitude and, as a tentative consequence, a significant decrease (p < 0.05) in the frequency of primary peristalsis was found only in patients operated on with a total fundic wrap. CONCLUSION: Despite adequate and durable reflux control after fundoplication in patients with chronic GORD, no change was found in oesophageal motor function with time. The higher contraction amplitude and decreased frequency of failed primary peristalsis seen in patients having a total fundic wrap were thus most likely due to a mechanical outflow obstruction in the gastro-oesophageal junction. These results could therefore be interpreted in favour of the hypothesis that GORD is pathogenetically linked to a primary defect in oesophageal motor function.
Authors: Marco Catarci; Paolo Gentileschi; Claudio Papi; Alessandro Carrara; Renato Marrese; Achille Lucio Gaspari; Giovanni Battista Grassi Journal: Ann Surg Date: 2004-03 Impact factor: 12.969
Authors: Georg R Linke; Andreas Zerz; Radu Tutuian; Francesco Marra; Rene Warschkow; Beat P Müller-Stich; Jan Borovicka Journal: J Gastrointest Surg Date: 2008-01-23 Impact factor: 3.452