Literature DB >> 9272389

Influence of a proton pump inhibitor-based therapy on Helicobacter pylori strain selection.

S L Hazell1, H M Mitchell, G Hanna, G Daskalopoulos.   

Abstract

The influence of the proton pump inhibitor lansoprazole on strain diversity in Helicobacter pylori infected patients was investigated. Multiple isolates of Helicobacter pylori obtained pre- and post-therapy from gastric antral and body biopsies in 22 patients were compared using the random amplified polymorphic DNA-polymerase chain reaction (RAPD-PCR) for analysis. Post-therapy strains exhibiting novel RAPD-profiles were found in 5 of 22 patients (4 of 11 patients treated with lansoprazole alone and 1 of 11 patients treated with lansoprazole plus amoxicillin). Proton pump inhibition may affect the microecology of the stomach by influencing the colonisation patterns of specific strains.

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Year:  1997        PMID： 9272389     DOI： 10.1007/bf01708237

Source DB:  PubMed          Journal:  Eur J Clin Microbiol Infect Dis        ISSN： 0934-9723            Impact factor:   3.267


  15 in total

1.  Meta-analysis of the efficacy of antibiotic therapy in eradicating Helicobacter pylori.

Authors:  N Chiba; B V Rao; J W Rademaker; R H Hunt
Journal:  Am J Gastroenterol       Date:  1992-12       Impact factor: 10.864

2.  Lansoprazole, a novel benzimidazole proton pump inhibitor, and its related compounds have selective activity against Helicobacter pylori.

Authors:  T Iwahi; H Satoh; M Nakao; T Iwasaki; T Yamazaki; K Kubo; T Tamura; A Imada
Journal:  Antimicrob Agents Chemother       Date:  1991-03       Impact factor: 5.191

3.  Multiple strain colonization and metronidazole resistance in Helicobacter pylori-infected patients: identification from sequential and multiple biopsy specimens.

Authors:  M Jorgensen; G Daskalopoulos; V Warburton; H M Mitchell; S L Hazell
Journal:  J Infect Dis       Date:  1996-09       Impact factor: 5.226

4.  Effect of acid suppression on efficacy of treatment for Helicobacter pylori infection.

Authors:  W de Boer; W Driessen; A Jansz; G Tytgat
Journal:  Lancet       Date:  1995-04-01       Impact factor: 79.321

5.  DNA diversity among clinical isolates of Helicobacter pylori detected by PCR-based RAPD fingerprinting.

Authors:  N Akopyanz; N O Bukanov; T U Westblom; S Kresovich; D E Berg
Journal:  Nucleic Acids Res       Date:  1992-10-11       Impact factor: 16.971

6.  DNA fingerprints of Helicobacter pylori before and after treatment with omeprazole.

Authors:  A G Fraser; J Bickley; R J Owen; R E Pounder
Journal:  J Clin Pathol       Date:  1992-12       Impact factor: 3.411

7.  Experience with 'triple' anti-Helicobacter pylori eradication therapy: side effects and the importance of testing the pre-treatment bacterial isolate for metronidazole resistance.

Authors:  G D Bell; K Powell; S M Burridge; A Pallecaros; P H Jones; P W Gant; G Harrison; J E Trowell
Journal:  Aliment Pharmacol Ther       Date:  1992-08       Impact factor: 8.171

8.  Single and multiple strain colonization in patients with Helicobacter pylori-associated gastritis: detection by macrorestriction DNA analysis.

Authors:  A M Hirschl; M Richter; A Makristathis; P M Prückl; B Willinger; K Schütze; M L Rotter
Journal:  J Infect Dis       Date:  1994-08       Impact factor: 5.226

9.  Long-term colonization with single and multiple strains of Helicobacter pylori assessed by DNA fingerprinting.

Authors:  N S Taylor; J G Fox; N S Akopyants; D E Berg; N Thompson; B Shames; L Yan; E Fontham; F Janney; F M Hunter
Journal:  J Clin Microbiol       Date:  1995-04       Impact factor: 5.948

10.  Characterization of chromosomal DNA profiles from Helicobacter pylori strains isolated from sequential gastric biopsy specimens.

Authors:  S M Salama; Q Jiang; N Chang; R W Sherbaniuk; D E Taylor
Journal:  J Clin Microbiol       Date:  1995-09       Impact factor: 5.948
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