Localization of neuropeptides in endocrine cells of the chicken thymus.

Interactions between endocrine cells and epithelial cells, mediated by neurotensin, have been proposed in the chicken thymus. In this study, other neuropeptide candidates acting as mediators in the chicken thymus were examined immunohistochemically. Endocrine cells being oval, elongated or triangular in shape were immunoreactive with antibodies against methionine-enkephalin, neuropeptide Y, substance P, and vasoactive intestinal peptide. These findings suggest that 4 neuropeptides may be involved in cell-to-cell interactions in the chicken thymus.