Literature DB >> 9270391

Multiorgan system failure caused by valproic acid toxicity.

R Pinkston1, L A Walker.   

Abstract

Valproic acid is an effective antiseizure medication that is also used for other indications such as migraine prophylaxis. It is known to sometimes cause hepatic injury, both a mild dose-related form and an idiosyncratic, fulminant, usually fatal type. A case is reported of multiorgan failure caused by valproic acid toxicity in an adult who survived. Such multisystem toxicity has not been previously reported.

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Year:  1997        PMID: 9270391     DOI: 10.1016/s0735-6757(97)90195-9

Source DB:  PubMed          Journal:  Am J Emerg Med        ISSN: 0735-6757            Impact factor:   2.469


  5 in total

1.  Valproic acid-induced pancreatitis.

Authors:  Chaker Ben Salem; Michel Biour; Houssem Hmouda; Andkamel Bouraoui
Journal:  J Gastroenterol       Date:  2007-07-25       Impact factor: 7.527

2.  Myotoxicity Induced by Antiepileptic Drugs: Could be a Rare but Serious Adverse Event?

Authors:  Antonio Siniscalchi; Scott Mintzer; Giovambattista De Sarro; Luca Gallelli
Journal:  Psychopharmacol Bull       Date:  2021-11-03

Review 3.  Dispensability of Annual Laboratory Follow-Up After More than 2 Years of Valproic Acid Use: A Systematic Review.

Authors:  Rosanne W Meijboom; Koen P Grootens
Journal:  CNS Drugs       Date:  2017-11       Impact factor: 5.749

4.  Fatal Liver and Bone Marrow Toxicity by Combination Treatment of Dichloroacetate and Artesunate in a Glioblastoma Multiforme Patient: Case Report and Review of the Literature.

Authors:  Martin Uhl; Stefan Schwab; Thomas Efferth
Journal:  Front Oncol       Date:  2016-10-07       Impact factor: 6.244

5.  Sodium Valproate Exacerbating an Underlying Disorder of Fatty Acid Metabolism.

Authors:  Jamie Bellinge; Sanjaya Herath; Dharmesh Sonigra
Journal:  Case Rep Neurol       Date:  2016-09-12
  5 in total

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