Literature DB >> 9268716

Induction of uncoupling protein-2 mRNA by troglitazone in the pancreatic islets of Zucker diabetic fatty rats.

M Shimabukuro1, Y T Zhou, Y Lee, R H Unger.   

Abstract

Because troglitazone, like leptin, lowers the triglyceride (TG) content of pancreatic islets, we searched for other leptinomimetic actions. Leptin upregulates the expression of uncoupling protein-2 (UCP-2) mRNA in islets of normal rats, but has no effect in islets of obese Zucker Diabetic Fatty (ZDF) rats with mutated leptin receptors. We report here that troglitazone also increases the UCP-2/beta-actin mRNA ratio by 115% in wild type ZDF rats and by 400% in obese ZDF rats.

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Year:  1997        PMID： 9268716     DOI： 10.1006/bbrc.1997.7140

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  7 in total

Review 1.  Uncoupling proteins: role in insulin resistance and insulin insufficiency.

Authors:  Catherine B Chan; Mary-Ellen Harper
Journal:  Curr Diabetes Rev       Date:  2006-08

Review 2.  The uncoupling protein homologues: UCP1, UCP2, UCP3, StUCP and AtUCP.

Authors:  D Ricquier; F Bouillaud
Journal:  Biochem J       Date:  2000-01-15       Impact factor: 3.857

3.  Chronic and acute effects of thiazolidinediones BM13.1258 and BM15.2054 on rat skeletal muscle glucose metabolism.

Authors:  C Fürnsinn; B Brunmair; M Meyer; S Neschen; R Furtmüller; M Roden; H F Kühnle; P Nowotny; B Schneider; W Waldhäusl
Journal:  Br J Pharmacol       Date:  1999-11       Impact factor: 8.739

4.  Association of upregulated activity of K(ATP) channels with impaired insulin secretion in UCP1-expressing insulinoma cells.

Authors:  Mitsuhiro Nakazaki; Masafumi Kakei; Hisamitsu Ishihara; Nobuyuki Koriyama; Hiroshi Hashiguchi; Katsumi Aso; Michiyo Fukudome; Yoshitomo Oka; Toshihiko Yada; Chuwa Tei
Journal:  J Physiol       Date:  2002-05-01       Impact factor: 5.182

5.  Development of infrared imaging to measure thermogenesis in cell culture: thermogenic effects of uncoupling protein-2, troglitazone, and beta-adrenoceptor agonists.

Authors:  M A Paulik; R G Buckholz; M E Lancaster; W S Dallas; E A Hull-Ryde; J E Weiel; J M Lenhard
Journal:  Pharm Res       Date:  1998-06       Impact factor: 4.200

6.  Regulation of uncoupling protein-2 mRNA in L6 myotubules: I: Thiazolidinediones stimulate uncoupling protein-2 gene expression by a mechanism requiring ongoing protein synthesis and an active mitogen-activated protein kinase.

Authors:  Irma López-Solache; Véronique Marie; Erika Vignault; Anne Camirand; J Enrique Silva
Journal:  Endocrine       Date:  2002-11       Impact factor: 3.925

7.  Transcriptional regulation of lipid metabolism by fatty acids: a key determinant of pancreatic beta-cell function.

Authors:  Zahra Fatehi-Hassanabad; Catherine B Chan
Journal:  Nutr Metab (Lond)       Date:  2005-01-05       Impact factor: 4.169
  7 in total

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