OBJECTIVES: In the course of a prospective multicenter trial, the value of tumor markers in seminomas was assessed. METHODS: Human chorionic gonadotropin (HCG), lactate dehydrogenase (LDH) and placental alkaline phosphatase (PlAP) were determined before and after orchidectomy and in the follow-up. Patients with elevated alpha-fetoprotein were considered to have nonseminomas. The half-lives were 24-36 h for HCG and 1 day for LDH and PlAP. RESULTS: The incidence of HCG, LDH and PlAP was 35, 34 and 56%, respectively. In 84% of the patients at least one of the three markers was elevated. PlAP had the highest sensitivity to detect metastatic disease (51%), with a specificity of 91%. HCG and LDH were elevated in 42 and 46% of patients in stage II-III with specificities of 95 and 96%. PlAP was the best method to indicate a relapse, but the specificity was low, especially in smokers. For nonsmokers it was in the same range as HCG and LDH. CONCLUSIONS: Eighty-four percent of seminomas are marker-positive. PlAP has the highest incidence and sensitivity. Specificity is impaired in smokers. All three markers should be determined in seminomas.
OBJECTIVES: In the course of a prospective multicenter trial, the value of tumor markers in seminomas was assessed. METHODS:Human chorionic gonadotropin (HCG), lactate dehydrogenase (LDH) and placental alkaline phosphatase (PlAP) were determined before and after orchidectomy and in the follow-up. Patients with elevated alpha-fetoprotein were considered to have nonseminomas. The half-lives were 24-36 h for HCG and 1 day for LDH and PlAP. RESULTS: The incidence of HCG, LDH and PlAP was 35, 34 and 56%, respectively. In 84% of the patients at least one of the three markers was elevated. PlAP had the highest sensitivity to detect metastatic disease (51%), with a specificity of 91%. HCG and LDH were elevated in 42 and 46% of patients in stage II-III with specificities of 95 and 96%. PlAP was the best method to indicate a relapse, but the specificity was low, especially in smokers. For nonsmokers it was in the same range as HCG and LDH. CONCLUSIONS: Eighty-four percent of seminomas are marker-positive. PlAP has the highest incidence and sensitivity. Specificity is impaired in smokers. All three markers should be determined in seminomas.
Authors: Klaus-Peter Dieckmann; Hanna Simonsen-Richter; Magdalena Kulejewski; Petra Anheuser; Henrik Zecha; Hendrik Isbarn; Uwe Pichlmeier Journal: Biomed Res Int Date: 2019-05-28 Impact factor: 3.411
Authors: Sérvio T Stinghen; Juliana F Moura; Patrícia Zancanella; Giovanna A Rodrigues; Mara A Pianovski; Enzo Lalli; Dodie L Arnold; João C Minozzo; Luis G Callefe; Raul C Ribeiro; Bonald C Figueiredo Journal: J Biomed Biotechnol Date: 2006
Authors: Christoph Seidel; Gedske Daugaard; Tim Nestler; Alexey Tryakin; Mikhail Fedyanin; Christian Daniel Fankhauser; Thomas Hermanns; Jorge Aparicio; Julia Heinzelbecker; Pia Paffenholz; Axel Heidenreich; Ugo De Giorgi; Richard Cathomas; Anja Lorch; Anna Fingerhut; Fabian Gayer; Felix Bremmer; Patrizia Giannatempo; Andrea Necchi; Daniele Raggi; Gaetano Aurilio; Chiara Casadei; Marcus Hentrich; Ben Tran; Klaus-Peter Dieckmann; Margarido Brito; Christian Ruf; Alessandro Mazzocca; Bruno Vincenzi; Olof Stahl; Carsten Bokemeyer; Christoph Oing Journal: World J Urol Date: 2021-03-08 Impact factor: 4.226