Literature DB >> 9265726

The state of antibody catalysis.

D B Smithrud1, S J Benkovic.   

Abstract

One of the fascinations of catalytic antibodies is the possibility of harnessing the mechanisms available to enzymes for chemical transformation and applying them to the broad realm of chemistry encountered in organic synthesis. Recently, the catalytic repertoire of antibodies has been extended to include mechanistically more complex bimolecular reactions and the immunological response to the hapten can be more thoroughly examined as a result of the advent of new screening technology using bacterial phages or auxotrophic cell lines.

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Year:  1997        PMID: 9265726     DOI: 10.1016/s0958-1669(97)80069-9

Source DB:  PubMed          Journal:  Curr Opin Biotechnol        ISSN: 0958-1669            Impact factor:   9.740


  2 in total

1.  One site fits both: a model for the ternary complex of folate + NADPH in R67 dihydrofolate reductase, a D2 symmetric enzyme.

Authors:  E E Howell; U Shukla; S N Hicks; R D Smiley; L A Kuhn; M I Zavodszky
Journal:  J Comput Aided Mol Des       Date:  2001-11       Impact factor: 3.686

2.  Protein dynamics and enzymatic chemical barrier passage.

Authors:  Dimitri Antoniou; Steven D Schwartz
Journal:  J Phys Chem B       Date:  2011-11-15       Impact factor: 2.991

  2 in total

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