| Literature DB >> 9263690 |
H Peters1, N A Noble, W A Border.
Abstract
Overexpression of the cytokine transforming growth factor-beta has been identified as the key mediator of chronic progressive kidney fibrosis in experimental and human kidney diseases. The renoprotective effects of angiotensin II blockade and low-protein diets have recently been linked to downregulation of transforming growth factor-beta production. Neutralizing the actions of transforming growth factor-beta by decorin gene therapy appears to be a highly effective new approach in the treatment of renal fibrosis.Entities:
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Year: 1997 PMID: 9263690 DOI: 10.1097/00041552-199707000-00014
Source DB: PubMed Journal: Curr Opin Nephrol Hypertens ISSN: 1062-4821 Impact factor: 2.894