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Literature DB >> 9263413

PrP genetics in sheep and the applications for scrapie and BSE.

Abstract

The strong links between PrP genotype and the occurrence of scrapie in sheep strengthen evidence supporting the central importance of the PrP protein in the development of transmissible spongiform encephalopathies, despite the fact that the cattle PrP gene has, so far, failed to show any association between PrP alleles and susceptibility to BSE.

Entities: Disease Gene Species

Mesh：

Substances：
Prions

Year: 1997 PMID： 9263413 DOI： 10.1016/s0966-842x(97)01081-0

Source DB: PubMed Journal: Trends Microbiol ISSN： 0966-842X Impact factor: 17.079

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Cited

48 in total

1. Full flexibility genotyping of single nucleotide polymorphisms by the GOOD assay.

Authors: S Sauer; D Lechner; K Berlin; C Plançon; A Heuermann; H Lehrach; I G Gut
Journal: Nucleic Acids Res Date: 2000-12-01 Impact factor: 16.971

2. The signature of scrapie: differences in the PrP genotype profile of scrapie-affected and scrapie-free UK sheep flocks.

Authors: M Baylis; F Houston; W Goldmann; N Hunter; A R McLean
Journal: Proc Biol Sci Date: 2000-10-22 Impact factor: 5.349

3. Molecular analysis of cases of Italian sheep scrapie and comparison with cases of bovine spongiform encephalopathy (BSE) and experimental BSE in sheep.

Authors: Romolo Nonno; Elena Esposito; Gabriele Vaccari; Michela Conte; Stefano Marcon; Michele Di Bari; Ciriaco Ligios; Giovanni Di Guardo; Umberto Agrimi
Journal: J Clin Microbiol Date: 2003-09 Impact factor: 5.948

4. Molecular evolution of the sheep prion protein gene.

Authors: Jon Slate
Journal: Proc Biol Sci Date: 2005-11-22 Impact factor: 5.349

Review 5. Animal breeding and disease.

Authors: Frank W Nicholas
Journal: Philos Trans R Soc Lond B Biol Sci Date: 2005-07-29 Impact factor: 6.237

PrP genetics in sheep and the applications for scrapie and BSE.

1. Full flexibility genotyping of single nucleotide polymorphisms by the GOOD assay.

2. The signature of scrapie: differences in the PrP genotype profile of scrapie-affected and scrapie-free UK sheep flocks.

3. Molecular analysis of cases of Italian sheep scrapie and comparison with cases of bovine spongiform encephalopathy (BSE) and experimental BSE in sheep.

4. Molecular evolution of the sheep prion protein gene.

Review 5. Animal breeding and disease.

6. Epidemiological analysis of data for scrapie in Great Britain.

7. Allelic frequency and genotypes of prion protein at codon 136 and 171 in Iranian Ghezel sheep breeds.

8. Eradication of scrapie with selective breeding: are we nearly there?

9. Pathogenesis of natural goat scrapie: modulation by host PRNP genotype and effect of co-existent conditions.

10. Ovine serum biomarkers of early and late phase scrapie.