Literature DB >> 9262182

Delayed neuronal death prevented by inhibition of increased hydroxyl radical formation in a transient cerebral ischemia.

T Yamamoto1, S Yuki, T Watanabe, M Mitsuka, K I Saito, K Kogure.   

Abstract

The salicylate-trapping method was used to detect hydroxyl radicals by measurement of stable adduct dihydroxybenzoic acid (DHBA). Ten minutes of forebrain ischemia followed by reperfusion induced the increase in DHBA in rat hippocampal perfusates. Postischemic treatment with a free radical scavenger, 3-methyl-1-phenyl-2-pyrazolin-5-one (MCI-186), significantly reduced the increase in DHBA and suppressed delayed neuronal death in the hippocampal CA1 region.

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Year:  1997        PMID： 9262182     DOI： 10.1016/s0006-8993(97)00490-3

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  46 in total

1.  Neuroprotective effects of N-methyl-D-aspartate receptor antagonist on aspartate induced neurotoxicity in the spinal cord in vivo.

Authors:  Yasunori Cho; Toshihiko Ueda; Atsuo Mori; Hideyuki Shimizu; Ryohei Yozu
Journal:  Jpn J Thorac Cardiovasc Surg       Date:  2003-10

2.  Edaravone, a free radical scavenger, protects components of the neurovascular unit against oxidative stress in vitro.

Authors:  Brian J Lee; Yasuhiro Egi; Klaus van Leyen; Eng H Lo; Ken Arai
Journal:  Brain Res       Date:  2009-10-17       Impact factor: 3.252

3.  Scavenging free radicals improves endothelial dysfunction in human coronary arteries in vivo.

Authors:  Jun-ichi Oyama; Shinji Satoh; Nobuhiro Suematsu; Toshiaki Kadokami; Toyoki Maeda; Masahiro Sugano; Naoki Makino
Journal:  Heart Vessels       Date:  2010-07-31       Impact factor: 2.037

4.  Hydrogen-rich saline solution attenuates renal ischemia-reperfusion injury.

Authors:  Chihiro Shingu; Hironori Koga; Satoshi Hagiwara; Shigekiyo Matsumoto; Koji Goto; Isao Yokoi; Takayuki Noguchi
Journal:  J Anesth       Date:  2010-05-18       Impact factor: 2.078

5.  A free radical scavenger edaravone suppresses systemic inflammatory responses in a rat transient focal ischemia model.

Authors:  Norio Fujiwara; Angel T Som; Loc-Duyen D Pham; Brian J Lee; Emiri T Mandeville; Eng H Lo; Ken Arai
Journal:  Neurosci Lett       Date:  2016-08-30       Impact factor: 3.046

6.  Edaravone protects against apoptotic neuronal cell death and improves cerebral function after traumatic brain injury in rats.

Authors:  Tatsuki Itoh; Takao Satou; Shozo Nishida; Masahiro Tsubaki; Motohiro Imano; Shigeo Hashimoto; Hiroyuki Ito
Journal:  Neurochem Res       Date:  2009-09-19       Impact factor: 3.996

7.  Assessment of the relative contribution of COX-1 and COX-2 isoforms to ischemia-induced oxidative damage and neurodegeneration following transient global cerebral ischemia.

Authors:  Eduardo Candelario-Jalil; Armando González-Falcón; Michel García-Cabrera; Dalia Alvarez; Said Al-Dalain; Gregorio Martínez; Olga Sonia León; Joe E Springer
Journal:  J Neurochem       Date:  2003-08       Impact factor: 5.372

8.  Beyond free radical scavenging: Beneficial effects of edaravone (Radicut) in various diseases (Review).

Authors:  Kiyoshi Kikuchi; Nobuyuki Takeshige; Naoki Miura; Yoko Morimoto; Takashi Ito; Salunya Tancharoen; Kei Miyata; Chiemi Kikuchi; Narumi Iida; Hisaaki Uchikado; Naohisa Miyagi; Naoto Shiomi; Terukazu Kuramoto; Ikuro Maruyama; Motohiro Morioka; Ko-Ichi Kawahara
Journal:  Exp Ther Med       Date:  2011-09-20       Impact factor: 2.447

9.  Safflor yellow B suppresses pheochromocytoma cell (PC12) injury induced by oxidative stress via antioxidant system and Bcl-2 /Bax pathway.

Authors:  Chaoyun Wang; Hongmei Ma; Shuping Zhang; Yuanfang Wang; Juntian Liu; Xianghua Xiao
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2009-05-08       Impact factor: 3.000

Review 10.  Molecular mechanisms of apoptosis in cerebral ischemia: multiple neuroprotective opportunities.

Authors:  Venkata Prasuja Nakka; Anchal Gusain; Suresh L Mehta; Ram Raghubir
Journal:  Mol Neurobiol       Date:  2007-12-08       Impact factor: 5.590
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