Literature DB >> 9261442

Enhanced downregulation of Lck-mediated signal transduction by a Y114 mutation of herpesvirus Saimiri tip.

J Guo1, M Duboise, H Lee, M Li, J K Choi, M Rosenzweig, J U Jung.   

Abstract

Tip of herpesvirus saimiri associates with Lck and downregulates Lck function in cellular signal transduction. In this report, we demonstrate that mutation of tyrosine 114 of Tip significantly increases Lck-binding activity. This mutant exhibits a dramatic increase in the suppression of cellular tyrosine phosphorylation and surface expression of lymphocyte antigens in comparison with wild-type Tip. In addition, the expression of TipY114 converted the transforming morphology of fibroblasts induced by oncogenic F505 Lck to a normal cellular morphology. These results further support a mechanism by which the association of Tip with Lck negatively regulates Lck-mediated signal transduction.

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Year:  1997        PMID： 9261442      PMCID： PMC192003     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  29 in total

1.  Superantigen function.

Authors:  B J Thomson; J Nicholas
Journal:  Nature       Date:  1991-06-13       Impact factor: 49.962

2.  Regulation of the enzymatic function of the lymphocyte-specific tyrosine protein kinase p56lck by the non-catalytic SH2 and SH3 domains.

Authors:  A Veillette; L Caron; M Fournel; T Pawson
Journal:  Oncogene       Date:  1992-05       Impact factor: 9.867

3.  Tap: a novel cellular protein that interacts with tip of herpesvirus saimiri and induces lymphocyte aggregation.

Authors:  D W Yoon; H Lee; W Seol; M DeMaria; M Rosenzweig; J U Jung
Journal:  Immunity       Date:  1997-05       Impact factor: 31.745

4.  A region of the Herpesvirus saimiri genome required for oncogenicity.

Authors:  R C Desrosiers; A Bakker; J Kamine; L A Falk; R D Hunt; N W King
Journal:  Science       Date:  1985-04-12       Impact factor: 47.728

5.  Nononcogenic deletion mutants of herpesvirus saimiri are defective for in vitro immortalization.

Authors:  R C Desrosiers; D P Silva; L M Waldron; N L Letvin
Journal:  J Virol       Date:  1986-02       Impact factor: 5.103

6.  Herpesvirus saimiri Tip-484 membrane protein markedly increases p56lck activity in T cells.

Authors:  T Lund; M M Medveczky; P G Medveczky
Journal:  J Virol       Date:  1997-01       Impact factor: 5.103

7.  The divergence between two oncogenic Herpesvirus saimiri strains in a genomic region related to the transforming phenotype.

Authors:  B Biesinger; J J Trimble; R C Desrosiers; B Fleckenstein
Journal:  Virology       Date:  1990-06       Impact factor: 3.616

8.  Identification of transforming genes of subgroup A and C strains of Herpesvirus saimiri.

Authors:  J U Jung; J J Trimble; N W King; B Biesinger; B W Fleckenstein; R C Desrosiers
Journal:  Proc Natl Acad Sci U S A       Date:  1991-08-15       Impact factor: 11.205

9.  Herpesvirus saimiri encodes homologues of G protein-coupled receptors and cyclins.

Authors:  J Nicholas; K R Cameron; R W Honess
Journal:  Nature       Date:  1992-01-23       Impact factor: 49.962

10.  Herpesvirus saimiri open reading frame 14, a protein encoded by T lymphotropic herpesvirus, binds to MHC class II molecules and stimulates T cell proliferation.

Authors:  Z Yao; E Maraskovsky; M K Spriggs; J I Cohen; R J Armitage; M R Alderson
Journal:  J Immunol       Date:  1996-05-01       Impact factor: 5.422
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  9 in total

Review 1.  Signaling activities of gammaherpesvirus membrane proteins.

Authors:  B Damania; J K Choi; J U Jung
Journal:  J Virol       Date:  2000-02       Impact factor: 5.103

Review 2.  Herpesvirus saimiri.

Authors:  H Fickenscher; B Fleckenstein
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2001-04-29       Impact factor: 6.237

3.  T-cell growth transformation by herpesvirus saimiri is independent of STAT3 activation.

Authors:  Elke Heck; Doris Lengenfelder; Monika Schmidt; Ingrid Müller-Fleckenstein; Bernhard Fleckenstein; Brigitte Biesinger; Armin Ensser
Journal:  J Virol       Date:  2005-05       Impact factor: 5.103

4.  STP and Tip are essential for herpesvirus saimiri oncogenicity.

Authors:  S M Duboise; J Guo; S Czajak; R C Desrosiers; J U Jung
Journal:  J Virol       Date:  1998-02       Impact factor: 5.103

5.  Downregulation of p56(lck) tyrosine kinase activity in T cells of squirrel monkeys (Saimiri sciureus) correlates with the nontransforming and apathogenic properties of herpesvirus saimiri in its natural host.

Authors:  T Greve; G Tamgüney; B Fleischer; H Fickenscher; B M Bröker
Journal:  J Virol       Date:  2001-10       Impact factor: 5.103

6.  Growth transformation of human T cells by herpesvirus saimiri requires multiple Tip-Lck interaction motifs.

Authors:  Elke Heck; Ute Friedrich; Michaela U Gack; Doris Lengenfelder; Monika Schmidt; Ingrid Müller-Fleckenstein; Bernhard Fleckenstein; Armin Ensser; Brigitte Biesinger
Journal:  J Virol       Date:  2006-10       Impact factor: 5.103

7.  Mutation of the Lck-binding motif of Tip enhances lymphoid cell activation by herpesvirus saimiri.

Authors:  S M Duboise; H Lee; J Guo; J K Choi; S Czajak; M Simon; R C Desrosiers; J U Jung
Journal:  J Virol       Date:  1998-04       Impact factor: 5.103

8.  Distinct roles of cellular Lck and p80 proteins in herpesvirus saimiri Tip function on lipid rafts.

Authors:  Junsoo Park; Nam-Hyuk Cho; Joong-Kook Choi; Pinghui Feng; Joonho Choe; Jae U Jung
Journal:  J Virol       Date:  2003-08       Impact factor: 5.103

9.  Modulating p56Lck in T-Cells by a Chimeric Peptide Comprising Two Functionally Different Motifs of Tip from Herpesvirus saimiri.

Authors:  Jean-Paul Vernot; Ana María Perdomo-Arciniegas; Luis Alberto Pérez-Quintero; Diego Fernando Martínez
Journal:  J Immunol Res       Date:  2015-10-11       Impact factor: 4.818
  9 in total

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