Literature DB >> 9259456

Serotonergic inhibition of phrenic motoneuron activity: an in vitro study in neonatal rat.

E Di Pasquale1, A Lindsay, J Feldman, R Monteau, G Hilaire.   

Abstract

In vitro experiments were conducted on neonatal rat brainstem-spinal cord preparations to test the hypothesis of an inhibitory modulation of phrenic activity by serotonin (5-HT) via non-5-HT2A receptors [Lindsay, A.D. and Feldman, J.L., Modulation of respiratory activity of neonatal rat phrenic motoneurones by serotonin, J. Physiol., 461 (1993) 213-233]. The changes induced by 5-HT and related agents on phrenic root discharges and membrane currents in identified phrenic motoneurons were analysed after blockade of spinal 5-HT2A receptors. Spinal application of 5-HT1B (but not 5-HT1A) receptor agonists depressed the phrenic activity and the effect was prevented by pretreatment with 5-HT1B (but not 5-HT1A, 5-HT2A and 5-HT3) receptor antagonists. Results from phrenic motoneuron whole cell recordings do not reject a presynaptic location of the 5-HT receptors responsible for this depression.

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Year:  1997        PMID： 9259456     DOI： 10.1016/s0304-3940(97)00469-2

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  20 in total

1.  Altered respiratory activity and respiratory regulations in adult monoamine oxidase A-deficient mice.

Authors:  H Burnet; M Bevengut; F Chakri; C Bou-Flores; P Coulon; S Gaytan; R Pasaro; G Hilaire
Journal:  J Neurosci       Date:  2001-07-15       Impact factor: 6.167

Review 2.  The serotonergic system and the control of breathing during development.

Authors:  Kevin J Cummings; Matthew R Hodges
Journal:  Respir Physiol Neurobiol       Date:  2019-07-27       Impact factor: 1.931

3.  Spinal activation of serotonin 1A receptors enhances latent respiratory activity after spinal cord injury.

Authors:  M Beth Zimmer; Harry G Goshgarian
Journal:  J Spinal Cord Med       Date:  2006       Impact factor: 1.985

Review 4.  Serotonergic transmission after spinal cord injury.

Authors:  Raffaele Nardone; Yvonne Höller; Aljoscha Thomschewski; Peter Höller; Piergiorgio Lochner; Stefan Golaszewski; Francesco Brigo; Eugen Trinka
Journal:  J Neural Transm (Vienna)       Date:  2014-05-28       Impact factor: 3.575

Review 5.  Synaptic control of motoneuronal excitability.

Authors:  J C Rekling; G D Funk; D A Bayliss; X W Dong; J L Feldman
Journal:  Physiol Rev       Date:  2000-04       Impact factor: 37.312

6.  Polysynaptic excitatory postsynaptic potentials that trigger spasms after spinal cord injury in rats are inhibited by 5-HT1B and 5-HT1F receptors.

Authors:  Katherine C Murray; Marilee J Stephens; Michelle Rank; Jessica D'Amico; Monica A Gorassini; David J Bennett
Journal:  J Neurophysiol       Date:  2011-06-08       Impact factor: 2.714

7.  Abnormal phrenic motoneuron activity and morphology in neonatal monoamine oxidase A-deficient transgenic mice: possible role of a serotonin excess.

Authors:  C Bou-Flores; A M Lajard; R Monteau; E De Maeyer; I Seif; J Lanoir; G Hilaire
Journal:  J Neurosci       Date:  2000-06-15       Impact factor: 6.167

8.  Altered respiratory motor drive after spinal cord injury: supraspinal and bilateral effects of a unilateral lesion.

Authors:  F J Golder; P J Reier; D C Bolser
Journal:  J Neurosci       Date:  2001-11-01       Impact factor: 6.167

9.  Reduction of spinal sensory transmission by facilitation of 5-HT1B/D receptors in noninjured and spinal cord-injured humans.

Authors:  Jessica M D'Amico; Yaqing Li; David J Bennett; Monica A Gorassini
Journal:  J Neurophysiol       Date:  2012-12-05       Impact factor: 2.714

Review 10.  Contributions of 5-HT neurons to respiratory control: neuromodulatory and trophic effects.

Authors:  Matthew R Hodges; George B Richerson
Journal:  Respir Physiol Neurobiol       Date:  2008-12-10       Impact factor: 1.931
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