Literature DB >> 9259287

Human mini-chromosomes in mouse embryonal stem cells.

M H Shen1, J Yang, M L Loupart, A Smith, W Brown.   

Abstract

We have introduced human mini-chromosomes of 4 Mb and approximately 15 Mb in size into mouse embryonal stem cells. Although these human mini-chromosomes are stable in hamster and chicken cells, they re-arrange or segregate aberrantly in the embryonal stem cells and are rapidly lost in the absence of selection. However, one of the mini-chromosomes re-arranged, acquired mouse centromeric sequences and was then stably maintained for at least 60 population doublings in culture. This mini-chromosome, which is 4 Mb in size, is a candidate for a mouse germ line chromosome vector.

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Year:  1997        PMID： 9259287     DOI： 10.1093/hmg/6.8.1375

Source DB:  PubMed          Journal:  Hum Mol Genet        ISSN： 0964-6906            Impact factor:   6.150


  11 in total

1.  1st International Conference on the Mammalian Centromere. Taichung, Taiwan, 2-4 October 1998. Abstracts.

Authors: 
Journal:  Chromosome Res       Date:  1998-12       Impact factor: 5.239

2.  Localisation of centromeric proteins to a fraction of mouse minor satellite DNA on a mini-chromosome in human, mouse and chicken cells.

Authors:  Kang Zeng; Jose I de las Heras; Andrew Ross; Jian Yang; Howard Cooke; Ming Hong Shen
Journal:  Chromosoma       Date:  2004-07-28       Impact factor: 4.316

3.  Double trans-chromosomic mice: maintenance of two individual human chromosome fragments containing Ig heavy and kappa loci and expression of fully human antibodies.

Authors:  K Tomizuka; T Shinohara; H Yoshida; H Uejima; A Ohguma; S Tanaka; K Sato; M Oshimura; I Ishida
Journal:  Proc Natl Acad Sci U S A       Date:  2000-01-18       Impact factor: 11.205

4.  Efficient male and female germline transmission of a human chromosomal vector in mice.

Authors:  T Voet; J Vermeesch; A Carens; J Dürr; C Labaere; H Duhamel; G David; P Marynen
Journal:  Genome Res       Date:  2001-01       Impact factor: 9.043

5.  Stability of transferred human chromosome fragments in cultured cells and in mice.

Authors:  T Shinohara; K Tomizuka; S Takehara; K Yamauchi; M Katoh; A Ohguma; I Ishida; M Oshimura
Journal:  Chromosome Res       Date:  2000       Impact factor: 5.239

6.  Construction of neocentromere-based human minichromosomes by telomere-associated chromosomal truncation.

Authors:  R Saffery; L H Wong; D V Irvine; M A Bateman; B Griffiths; S M Cutts; M R Cancilla; A C Cendron; A J Stafford; K H Choo
Journal:  Proc Natl Acad Sci U S A       Date:  2001-05-01       Impact factor: 11.205

7.  An unpaired mouse centromere passes consistently through male meiosis and does not significantly compromise spermatogenesis.

Authors:  P Joseph Mee; Ming Hong Shen; Austin G Smith; William R A Brown
Journal:  Chromosoma       Date:  2003-11-08       Impact factor: 4.316

Review 8.  Human artificial chromosome vectors meet stem cells: new prospects for gene delivery.

Authors:  Xianying Ren; Candice Ginn T Tahimic; Motonobu Katoh; Akihiro Kurimasa; Toshiaki Inoue; Mitsuo Oshimura
Journal:  Stem Cell Rev       Date:  2006       Impact factor: 6.692

Review 9.  A pathway from chromosome transfer to engineering resulting in human and mouse artificial chromosomes for a variety of applications to bio-medical challenges.

Authors:  Mitsuo Oshimura; Narumi Uno; Yasuhiro Kazuki; Motonobu Katoh; Toshiaki Inoue
Journal:  Chromosome Res       Date:  2015-02       Impact factor: 5.239

10.  Rearranging the centromere of the human Y chromosome with phiC31 integrase.

Authors:  Sunir Malla; Felix Dafhnis-Calas; John F Y Brookfield; Margaret C M Smith; William R A Brown
Journal:  Nucleic Acids Res       Date:  2005-10-24       Impact factor: 16.971
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