Literature DB >> 9258349

An orally bioavailable pyrrolinone inhibitor of HIV-1 protease: computational analysis and X-ray crystal structure of the enzyme complex.

A B Smith1, R Hirschmann, A Pasternak, W Yao, P A Sprengeler, M K Holloway, L C Kuo, Z Chen, P L Darke, W A Schleif.   

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Year:  1997        PMID: 9258349     DOI: 10.1021/jm970195u

Source DB:  PubMed          Journal:  J Med Chem        ISSN: 0022-2623            Impact factor:   7.446


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  5 in total

1.  Transport characteristics of peptidomimetics. Effect of the pyrrolinone bioisostere on transport across Caco-2 cell monolayers.

Authors:  M Sudoh; G M Pauletti; W Yao; W Moser; A Yokoyama; A Pasternak; P A Sprengeler; A B Smith; R Hirschmann; R T Borchardt
Journal:  Pharm Res       Date:  1998-05       Impact factor: 4.200

2.  Pyrrolinone-based peptidomimetics. "Let the enzyme or receptor be the judge".

Authors:  Amos B Smith; Adam K Charnley; Ralph Hirschmann
Journal:  Acc Chem Res       Date:  2010-12-22       Impact factor: 22.384

3.  NMR structure of a complex between MDM2 and a small molecule inhibitor.

Authors:  David C Fry; S Donald Emerson; Stefan Palme; Binh T Vu; Chao-Min Liu; Frank Podlaski
Journal:  J Biomol NMR       Date:  2004-10       Impact factor: 2.835

4.  Structure-activity relationships for inhibition of cysteine protease activity and development of Plasmodium falciparum by peptidyl vinyl sulfones.

Authors:  Bhaskar R Shenai; Belinda J Lee; Alejandro Alvarez-Hernandez; Pek Y Chong; Cory D Emal; R Jeffrey Neitz; William R Roush; Philip J Rosenthal
Journal:  Antimicrob Agents Chemother       Date:  2003-01       Impact factor: 5.191

5.  New cathepsin D inhibitor library utilizing hydroxyethyl isosteres with cyclic tertiary amines.

Authors:  Rose M McConnell; Kalyani Inapudi; Naveen Kadasala; Karthika Yarlagadda; Priya Velusamy; Matthew S McConnell; Adam Green; Carol Trana; Kelley Sayyar; James S McConnell
Journal:  Med Chem       Date:  2012-11       Impact factor: 2.745

  5 in total

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