Literature DB >> 9257777

Comparison of single-dose oral grepafloxacin with cefixime for treatment of uncomplicated gonorrhea in men. The STD Study Group.

E W Hook1, W M McCormack, D Martin, R B Jones, K Bean, A N Maroli.   

Abstract

In a randomized open study, 351 male patients with uncomplicated gonorrhea were given single oral doses of grepafloxacin (400 mg) or cefixime (400 mg). In the 299 microbiologically evaluable patients, urethral infections were cured in 99% (147 of 149) of those receiving grepafloxacin and 97% (145 of 150) of those given cefixime. Eradication rates for both regimens were 100% in the 16% (47 of 299) of participants who were infected with penicillin-resistant Neisseria gonorrhoeae and 97% in the 21% (62 of 299) of participants infected with tetracycline-resistant strains. Grepafloxacin is a well-tolerated alternative to cefixime for treatment of uncomplicated gonorrhea in males.

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Year:  1997        PMID： 9257777      PMCID： PMC164021     

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  6 in total

1.  In vitro and in vivo antichlamydial activities of newly developed quinolone antimicrobial agents.

Authors:  M Kimura; T Kishimoto; Y Niki; R Soejima
Journal:  Antimicrob Agents Chemother       Date:  1993-04       Impact factor: 5.191

2.  Concentrations of OPC-17116, a new fluoroquinolone antibacterial, in serum and lung compartments.

Authors:  P J Cook; J M Andrews; R Wise; D Honeybourne; H Moudgil
Journal:  J Antimicrob Chemother       Date:  1995-02       Impact factor: 5.790

3.  The in-vitro activity of OPC-17116, a new 5-methyl substituted quinolone.

Authors:  R Wise; J M Andrews; N Brenwald
Journal:  J Antimicrob Chemother       Date:  1993-04       Impact factor: 5.790

4.  Antibacterial activities of OPC-17116, ofloxacin, and ciprofloxacin against 200 isolates of Neisseria gonorrhoeae.

Authors:  J M Zenilman; T Neumann; M Patton; C Reichart
Journal:  Antimicrob Agents Chemother       Date:  1993-10       Impact factor: 5.191

5.  Novel method for detection of beta-lactamases by using a chromogenic cephalosporin substrate.

Authors:  C H O'Callaghan; A Morris; S M Kirby; A H Shingler
Journal:  Antimicrob Agents Chemother       Date:  1972-04       Impact factor: 5.191

Review 6.  Drugs of choice for the treatment of uncomplicated gonococcal infections.

Authors:  J S Moran; W C Levine
Journal:  Clin Infect Dis       Date:  1995-04       Impact factor: 9.079
  6 in total
  6 in total

Review 1.  Quinolones in sexually transmitted diseases: state of the art.

Authors:  G L Ridgway
Journal:  Drugs       Date:  1999       Impact factor: 9.546

2.  Emergence and spread of Neisseria gonorrhoeae clinical isolates harboring mosaic-like structure of penicillin-binding protein 2 in Central Japan.

Authors:  Masayasu Ito; Takashi Deguchi; Koh-Suke Mizutani; Mitsuru Yasuda; Shigeaki Yokoi; Shin-Ichi Ito; Yoshito Takahashi; Satoshi Ishihara; Yoshiaki Kawamura; Takayuki Ezaki
Journal:  Antimicrob Agents Chemother       Date:  2005-01       Impact factor: 5.191

Review 3.  Potential interactions of the extended-spectrum fluoroquinolones with the CNS.

Authors:  H Lode
Journal:  Drug Saf       Date:  1999-08       Impact factor: 5.606

Review 4.  Concurrent gonococcal and chlamydial infection: how best to treat.

Authors:  A J Robinson; G L Ridgway
Journal:  Drugs       Date:  2000-04       Impact factor: 9.546

5.  The new fluoroquinolones: A critical review.

Authors:  G G Zhanel; A Walkty; L Vercaigne; J A Karlowsky; J Embil; A S Gin; D J Hoban
Journal:  Can J Infect Dis       Date:  1999-05

Review 6.  Grepafloxacin.

Authors:  A J Wagstaff; J A Balfour
Journal:  Drugs       Date:  1997-05       Impact factor: 9.546
  6 in total

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