Literature DB >> 9256257

TNF-alpha downregulates the peroxisome proliferator activated receptor-alpha and the mRNAs encoding peroxisomal proteins in rat liver.

K Beier1, A Völkl, H D Fahimi.   

Abstract

We have studied the effects of TNF-alpha on the mRNAs coding for the peroxisome proliferator activated receptor alpha (PPAR-alpha), and for catalase (Cat), acyl-CoA oxidase (AOX), multifunctional enzyme (PH), and beta-actin in rat liver. Total RNA was isolated from livers of male SD-rats 16 h after administration of a single dose of 25 microg TNF-alpha and mRNAs were analyzed by a novel dot blot RNase protection assay. The mRNAs for PPAR-alpha and for Cat, AOX and PH were significantly reduced by TNF-treatment. In addition, the level of PPAR-alpha protein was also decreased after TNF. In contrast, the mRNA for beta-actin was markedly increased implying that the effect of TNF on PPAR-alpha and the peroxisomal mRNAs is highly selective. This effect may have important implications in perturbation of the lipid metabolism induced by TNF-alpha.

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Year:  1997        PMID： 9256257     DOI： 10.1016/s0014-5793(97)00805-3

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  21 in total

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Journal:  Proc Natl Acad Sci U S A       Date:  2015-04-06       Impact factor: 11.205

2.  Dietary supplementation of herring roe and milt enhances hepatic fatty acid catabolism in female mice transgenic for hTNFα.

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4.  Immunohistochemical distribution of activated nuclear factor kappaB and peroxisome proliferator-activated receptors in carbon tetrachloride-induced chronic liver injury in rats.

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5.  Regulatory T cells suppress excessive lipid accumulation in alcoholic liver disease.

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Review 6.  Genetic-dependency of peroxisomal cell functions - emerging aspects.

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Review 7.  Peroxisomal dysfunction in inflammatory childhood white matter disorders: an unexpected contributor to neuropathology.

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Review 8.  Mammalian peroxisomes and reactive oxygen species.

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9.  Hepatic NF-kappa B essential modulator deficiency prevents obesity-induced insulin resistance but synergizes with high-fat feeding in tumorigenesis.

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10.  The peroxisome: still a mysterious organelle.

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Journal:  Histochem Cell Biol       Date:  2008-02-15       Impact factor: 4.304
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