Literature DB >> 9256170

Suppressive effects of tranilast on the expression of inducible cyclooxygenase (COX2) in interleukin-1beta-stimulated fibroblasts.

H Inoue1, H Ohshima, H Kono, M Yamanaka, T Kubota, M Aihara, T Hiroi, N Yago, H Ishida.   

Abstract

We investigated the effects of tranilast on inducible cyclooxygenase (COX2)-mediated prostaglandin E2 (PGE2) production and enzyme induction in interleukin-lbeta (IL-1beta)-stimulated cultured dermal fibroblasts. IL-1beta enhanced PGE2 production in cultured fibroblasts. Tranilast did not affect constitutive cyclooxygenase (COX1) or COX2 activity in non-stimulated or IL-lbeta-stimulated fibroblasts. However, the COX2 expression induced by IL-1beta was inhibited by tranilast. This result, that IL-1beta-induced COX2 expression was suppressed by tranilast, was confirmed by immunohistochemical analysis. Thus, it is possible for tranilast to regulate PGE2 production by inhibiting COX2 induction.

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Year:  1997        PMID： 9256170     DOI： 10.1016/s0006-2952(97)00187-1

Source DB:  PubMed          Journal:  Biochem Pharmacol        ISSN： 0006-2952            Impact factor:   5.858


  5 in total

1.  N-[3,4-dimethoxycinnamoyl]-anthranilic acid (tranilast) suppresses microglial inducible nitric oxide synthase (iNOS) expression and activity induced by interferon-gamma (IFN-gamma).

Authors:  M Platten; W Wick; J Wischhusen; M Weller
Journal:  Br J Pharmacol       Date:  2001-11       Impact factor: 8.739

2.  Proliferative action of mast-cell tryptase is mediated by PAR2, COX2, prostaglandins, and PPARgamma : Possible relevance to human fibrotic disorders.

Authors:  Mónica B Frungieri; Stephan Weidinger; Viktor Meineke; Frank M Köhn; Artur Mayerhofer
Journal:  Proc Natl Acad Sci U S A       Date:  2002-10-23       Impact factor: 11.205

3.  Pharmacological evaluation of the semi-purified fractions from the soft coral Eunicella singularis and isolation of pure compounds.

Authors:  Monia Deghrigue; Carmen Festa; Lotfi Ghribi; Maria Valeria D'auria; Simona de Marino; Hichem Ben Jannet; Rafik Ben Said; Abderrahman Bouraoui
Journal:  Daru       Date:  2014-09-10       Impact factor: 3.117

4.  Membrane-associated prostaglandin E synthase-1 is upregulated by proinflammatory cytokines in chondrocytes from patients with osteoarthritis.

Authors:  Fumiaki Kojima; Hiroaki Naraba; Satoshi Miyamoto; Moroe Beppu; Haruhito Aoki; Shinichi Kawai
Journal:  Arthritis Res Ther       Date:  2004-06-08       Impact factor: 5.156

Review 5.  Biological Activities, Health Benefits, and Therapeutic Properties of Avenanthramides: From Skin Protection to Prevention and Treatment of Cerebrovascular Diseases.

Authors:  Andrea Perrelli; Luca Goitre; Anna Maria Salzano; Andrea Moglia; Andrea Scaloni; Saverio Francesco Retta
Journal:  Oxid Med Cell Longev       Date:  2018-08-23       Impact factor: 6.543
  5 in total

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