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Literature DB >> 9255069

Phosphoinositide 3-kinases: a conserved family of signal transducers.

B Vanhaesebroeck¹, S J Leevers, G Panayotou, M D Waterfield.

Abstract

Phosphoinositide 3-kinases (PI3Ks) generate lipids that are implicated in receptor-stimulated signalling and in the regulation of membrane traffic. Several distinct classes of PI3Ks have now been identified that have been conserved throughout eukaryotic evolution. Potential signalling pathways downstream of PI3Ks have been elucidated and PI3K function is now being characterised in several model organisms.

Entities: Chemical Gene

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Year: 1997 PMID： 9255069 DOI： 10.1016/s0968-0004(97)01061-x

Source DB: PubMed Journal: Trends Biochem Sci ISSN： 0968-0004 Impact factor: 13.807

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Cited

219 in total

1. Platelet-derived growth factor beta receptor regulates interstitial fluid homeostasis through phosphatidylinositol-3' kinase signaling.

Authors: R Heuchel; A Berg; M Tallquist; K Ahlén; R K Reed; K Rubin; L Claesson-Welsh; C H Heldin; P Soriano
Journal: Proc Natl Acad Sci U S A Date: 1999-09-28 Impact factor: 11.205

2. Ras effector pathway activation by epidermal growth factor is inhibited in vivo by exoenzyme S ADP-ribosylation of Ras.

Authors: M L Henriksson; R Rosqvist; M Telepnev; H Wolf-Watz; B Hallberg
Journal: Biochem J Date: 2000-04-01 Impact factor: 3.857

3. v-Crk activates the phosphoinositide 3-kinase/AKT pathway in transformation.

Authors: T Akagi; T Shishido; K Murata; H Hanafusa
Journal: Proc Natl Acad Sci U S A Date: 2000-06-20 Impact factor: 11.205

4. Most central nervous system D2 dopamine receptors are coupled to their effectors by Go.

Authors: M Jiang; K Spicher; G Boulay; Y Wang; L Birnbaumer
Journal: Proc Natl Acad Sci U S A Date: 2001-03-06 Impact factor: 11.205

5. Autophosphorylation of p110delta phosphoinositide 3-kinase: a new paradigm for the regulation of lipid kinases in vitro and in vivo.

Authors: B Vanhaesebroeck; K Higashi; C Raven; M Welham; S Anderson; P Brennan; S G Ward; M D Waterfield
Journal: EMBO J Date: 1999-03-01 Impact factor: 11.598

10. Upregulation of phosphoinositide 3-kinase and protein kinase B in alveolar macrophages following ozone inhalation. Role of NF-kappaB and STAT-1 in ozone-induced nitric oxide production and toxicity.

Authors: Debra L Laskin; Ladan Fakhrzadeh; Diane E Heck; Donald Gerecke; Jeffrey D Laskin
Journal: Mol Cell Biochem Date: 2002 May-Jun Impact factor: 3.396

Phosphoinositide 3-kinases: a conserved family of signal transducers.

1. Platelet-derived growth factor beta receptor regulates interstitial fluid homeostasis through phosphatidylinositol-3' kinase signaling.

2. Ras effector pathway activation by epidermal growth factor is inhibited in vivo by exoenzyme S ADP-ribosylation of Ras.

3. v-Crk activates the phosphoinositide 3-kinase/AKT pathway in transformation.

4. Most central nervous system D2 dopamine receptors are coupled to their effectors by Go.

5. Autophosphorylation of p110delta phosphoinositide 3-kinase: a new paradigm for the regulation of lipid kinases in vitro and in vivo.

6. Negative regulation of PI 3-kinase by Ruk, a novel adaptor protein.

Review 7. T cell signal transduction and the role of CD7 in costimulation.

8. Cellular signaling during the macrophage invasion by Trypanosoma cruzi.

9. The conserved phosphoinositide 3-kinase pathway determines heart size in mice.

10. Upregulation of phosphoinositide 3-kinase and protein kinase B in alveolar macrophages following ozone inhalation. Role of NF-kappaB and STAT-1 in ozone-induced nitric oxide production and toxicity.