M Kondo1, L Wang, A Bill. 1. Department of Physiology and Medical Biophysics, University of Uppsala, Sweden.
Abstract
PURPOSE: To elucidate the role of nitric oxide (NO) in the eye and the flicker-induced vascular response. METHODS: The blood flow in the retina and different parts of the optic nerve was compared in cats treated with the NO-synthase blocker, N(G)-nitro-L-arginine methyl ester and in control animals. In both groups, one of the eyes was dark-adapted, the other was subjected to 8 Hz flickering light. The regional blood flow was measured with the microsphere method. RESULTS: In control animals, flickering light increased blood flow in the retina and optic nerve head by 39% and 256%, respectively. Pretreatment with N(G)-nitro-L-arginine methyl ester prevented this increase in retinal blood flow and markedly reduced the blood flow in the optic nerve heads. CONCLUSION: NO release may mediate much of the vasodilating effect of flicker in cats, and play a role in maintaining normal vascular tone in the optic nerve head.
PURPOSE: To elucidate the role of nitric oxide (NO) in the eye and the flicker-induced vascular response. METHODS: The blood flow in the retina and different parts of the optic nerve was compared in cats treated with the NO-synthase blocker, N(G)-nitro-L-arginine methyl ester and in control animals. In both groups, one of the eyes was dark-adapted, the other was subjected to 8 Hz flickering light. The regional blood flow was measured with the microsphere method. RESULTS: In control animals, flickering light increased blood flow in the retina and optic nerve head by 39% and 256%, respectively. Pretreatment with N(G)-nitro-L-arginine methyl ester prevented this increase in retinal blood flow and markedly reduced the blood flow in the optic nerve heads. CONCLUSION: NO release may mediate much of the vasodilating effect of flicker in cats, and play a role in maintaining normal vascular tone in the optic nerve head.
Authors: Mary E J Lott; Julia E Slocomb; Vikram Shivkumar; Bruce Smith; David Quillen; Robert A Gabbay; Thomas W Gardner; Kerstin Bettermann Journal: Acta Ophthalmol Date: 2013-06-07 Impact factor: 3.761
Authors: Charles Ginsberg; Alfons J H M Houben; Rakesh Malhotra; Tos T J M Berendschot; Pieter C Dagnelie; Jeroen P Kooman; Caroll A Webers; Coen D A Stehouwer; Joachim H Ix Journal: Clin J Am Soc Nephrol Date: 2019-09-20 Impact factor: 8.237
Authors: Thomas Forst; Matthias M Weber; Michael Mitry; Lena Müller; Senait Forst; Mukkadar Tanis; Andreas Pfützner; Georg Michelson Journal: J Diabetes Sci Technol Date: 2014-02-21
Authors: Thanh T Nguyen; Ryo Kawasaki; Jie Jin Wang; Andreas J Kreis; Jonathan Shaw; Walthard Vilser; Tien Y Wong Journal: Diabetes Care Date: 2009-07-29 Impact factor: 17.152