Literature DB >> 9253713

Genetic control of interleukin 12 responsiveness: implications for disease pathogenesis.

J D Gorham1, M L Güler, K M Murphy.   

Abstract

We examined the effect of genetic background on Th1/Th2 development. We discuss data demonstrating that genetic background is an important determinant of interleukin-12 (IL-12) responsiveness and the potential implications for disease progression in murine experimental leishmaniasis. Genetic analysis of the differential control of IL-12 responsiveness led to the identification of a controlling locus on the middle portion of murine chromosome 11. This genetic region (or its human counterpart, 5q31) has been associated with increased disease susceptibilities for several atopic, infectious, and autoimmune disorders. We discuss potential roles for genetic control of IL-12 responsiveness in the development of these diseases.

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Year:  1997        PMID： 9253713     DOI： 10.1007/s001090050135

Source DB:  PubMed          Journal:  J Mol Med (Berl)        ISSN： 0946-2716            Impact factor:   4.599


  9 in total

Review 1.  Molecular mechanisms in T helper phenotype development.

Authors:  J D Farrar; S H Ranganath; K M Murphy
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2.  Transgenic expression of CXCR3 on T cells enhances susceptibility to cutaneous Leishmania major infection by inhibiting monocyte maturation and promoting a Th2 response.

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3.  Distinct roles for transforming growth factor-beta2 and tumour necrosis factor-alpha in immune deviation elicited by hapten-derivatized antigen-presenting cells.

Authors:  K H Hecker; H Niizeki; J W Streilein
Journal:  Immunology       Date:  1999-03       Impact factor: 7.397

4.  Presence of Lps(d) mutation influences cytokine regulation in vivo by the Mycoplasma arthritidis mitogen superantigen and lethal toxicity in mice infected with M. arthritidis.

Authors:  H H Mu; A D Sawitzke; B C Cole
Journal:  Infect Immun       Date:  2001-06       Impact factor: 3.441

Review 5.  Modulating the Th1/Th2 balance in inflammatory arthritis.

Authors:  B Müller; U Gimsa; N A Mitchison; A Radbruch; J Sieper; Z Yin
Journal:  Springer Semin Immunopathol       Date:  1998

6.  Friend of GATA-1 represses GATA-3-dependent activity in CD4+ T cells.

Authors:  M Zhou; W Ouyang; Q Gong; S G Katz; J M White; S H Orkin; K M Murphy
Journal:  J Exp Med       Date:  2001-11-19       Impact factor: 14.307

7.  Dose-dependent induction of murine Th1/Th2 responses to sheep red blood cells occurs in two steps: antigen presentation during second encounter is decisive.

Authors:  Claudia Stamm; Julia Barthelmann; Natalia Kunz; Kai-Michael Toellner; Jürgen Westermann; Kathrin Kalies
Journal:  PLoS One       Date:  2013-06-28       Impact factor: 3.240

8.  Uptake of Leishmania major amastigotes results in activation and interleukin 12 release from murine skin-derived dendritic cells: implications for the initiation of anti-Leishmania immunity.

Authors:  E von Stebut; Y Belkaid; T Jakob; D L Sacks; M C Udey
Journal:  J Exp Med       Date:  1998-10-19       Impact factor: 14.307

9.  CD4+ T cell polarization in mice is modulated by strain-specific major histocompatibility complex-independent differences within dendritic cells.

Authors:  Christophe Filippi; Stephanie Hugues; Julie Cazareth; Valerie Julia; Nicolas Glaichenhaus; Sophie Ugolini
Journal:  J Exp Med       Date:  2003-07-14       Impact factor: 14.307
  9 in total

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