| Literature DB >> 9253407 |
Y H Lee, T W Olson, C M Ogata, D G Levitt, L J Banaszak, A J Lange.
Abstract
The crystal structure of the fructose-2,6-bisphosphatase domain trapped during the reaction reveal a phosphorylated His 258, and a water molecule immobilized by the product, fructose-6-phosphate. The geometry suggests that the dephosphorylation step requires prior removal of the product for an 'associative in-line' phosphoryl transfer to the catalytic water.Entities:
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Year: 1997 PMID： 9253407 DOI： 10.1038/nsb0897-615
Source DB: PubMed Journal: Nat Struct Biol ISSN： 1072-8368