Literature DB >> 9253406

Three-dimensional structure of the Ras-interacting domain of RalGDS.

L Huang, X Weng, F Hofer, G S Martin, S H Kim.   

Abstract

The Ras-interacting domains of the the protein-kinase Raf and the Ral guanine nucleotide dissociation stimulator, RalGDS, lack extensive sequence similarity, but their overall three-dimensional structures are very similar to each other. Mutational analysis indicated that three residues in the RalGDS domain are critical for its interaction with Ras.

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Year:  1997        PMID: 9253406     DOI: 10.1038/nsb0897-609

Source DB:  PubMed          Journal:  Nat Struct Biol        ISSN: 1072-8368


  18 in total

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Journal:  J Biomol NMR       Date:  2002-08       Impact factor: 2.835

2.  Self-association mediated by the Ras association 1 domain of AF6 activates the oncogenic potential of MLL-AF6.

Authors:  Michaela Liedtke; Paul M Ayton; Tim C P Somervaille; Kevin S Smith; Michael L Cleary
Journal:  Blood       Date:  2010-04-15       Impact factor: 22.113

Review 3.  Turning off AKT: PHLPP as a drug target.

Authors:  Alexandra C Newton; Lloyd C Trotman
Journal:  Annu Rev Pharmacol Toxicol       Date:  2014       Impact factor: 13.820

4.  Protein-protein recognition: an experimental and computational study of the R89K mutation in Raf and its effect on Ras binding.

Authors:  J Zeng; M Fridman; H Maruta; H R Treutlein; T Simonson
Journal:  Protein Sci       Date:  1999-01       Impact factor: 6.725

5.  The Ubp6 family of deubiquitinating enzymes contains a ubiquitin-like domain: SUb.

Authors:  A M Wyndham; R T Baker; G Chelvanayagam
Journal:  Protein Sci       Date:  1999-06       Impact factor: 6.725

6.  The RA domain of Ste50 adaptor protein is required for delivery of Ste11 to the plasma membrane in the filamentous growth signaling pathway of the yeast Saccharomyces cerevisiae.

Authors:  Dagmar M Truckses; Joshua E Bloomekatz; Jeremy Thorner
Journal:  Mol Cell Biol       Date:  2006-02       Impact factor: 4.272

7.  The tumor suppressor RASSF1A is a novel effector of small G protein Rap1A.

Authors:  Sunil K Verma; Trivadi S Ganesan; Uday Kishore; Peter J Parker
Journal:  Protein Cell       Date:  2011-04-06       Impact factor: 14.870

8.  Structure, dynamics, lipid binding, and physiological relevance of the putative GTPase-binding domain of Dictyostelium formin C.

Authors:  Sonja A Dames; Alexander Junemann; Hans J Sass; André Schönichen; Barbara E Stopschinski; Stephan Grzesiek; Jan Faix; Matthias Geyer
Journal:  J Biol Chem       Date:  2011-08-16       Impact factor: 5.157

9.  The structure of the ternary complex of Krev interaction trapped 1 (KRIT1) bound to both the Rap1 GTPase and the heart of glass (HEG1) cytoplasmic tail.

Authors:  Alexandre R Gingras; Wilma Puzon-McLaughlin; Mark H Ginsberg
Journal:  J Biol Chem       Date:  2013-06-27       Impact factor: 5.157

10.  Structural and functional studies of the Ras-associating and pleckstrin-homology domains of Grb10 and Grb14.

Authors:  Rafael S Depetris; Jinhua Wu; Stevan R Hubbard
Journal:  Nat Struct Mol Biol       Date:  2009-08-02       Impact factor: 15.369

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