Literature DB >> 9252035

17beta-Estradiol protects against NMDA-induced excitotoxicity by direct inhibition of NMDA receptors.

C E Weaver1, M Park-Chung, T T Gibbs, D H Farb.   

Abstract

Several lines of evidence suggest that 17beta-estradiol (betaE2) has neuroprotective properties. The risk and severity of dementia are decreased in women who have received estrogen therapy, and betaE2 protects neurons in vitro against death from a variety of stressors. Neuroprotection by betaE2 has been suggested to be due to free radical scavenging. We demonstrate an additional neuroprotective mechanism whereby betaE2 protects against NMDA-induced neuronal death by directly inhibiting the NMDA receptor.

Entities:  

Mesh：

Substances：

Year:  1997        PMID： 9252035     DOI： 10.1016/s0006-8993(97)00449-6

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  45 in total

1.  Glutamate receptor requirement for neuronal death from anoxia-reoxygenation: an in Vitro model for assessment of the neuroprotective effects of estrogens.

Authors:  L L Zaulyanov; P S Green; J W Simpkins
Journal:  Cell Mol Neurobiol       Date:  1999-12       Impact factor: 5.046

2.  The effects of estradiol on estrogen receptor and glutamate transporter expression in organotypic hippocampal cultures exposed to oxygen--glucose deprivation.

Authors:  Helena Cimarosti; Ross D O'Shea; Nicole M Jones; Ana Paula Horn; Fabrício Simão; Lauren L Zamin; Melissa Nassif; Rudimar Frozza; Carlos Alexandre Netto; Philip M Beart; Christianne Salbego
Journal:  Neurochem Res       Date:  2006-05-09       Impact factor: 3.996

Review 3.  Functional significance of the rapid regulation of brain estrogen action: where do the estrogens come from?

Authors:  Charlotte A Cornil; Gregory F Ball; Jacques Balthazart
Journal:  Brain Res       Date:  2006-09-15       Impact factor: 3.252

Review 4.  Mitochondrial nuclear receptors and transcription factors: who's minding the cell?

Authors:  Junghee Lee; Swati Sharma; Jinho Kim; Robert J Ferrante; Hoon Ryu
Journal:  J Neurosci Res       Date:  2008-04       Impact factor: 4.164

Review 5.  Protective actions of sex steroid hormones in Alzheimer's disease.

Authors:  Christian J Pike; Jenna C Carroll; Emily R Rosario; Anna M Barron
Journal:  Front Neuroendocrinol       Date:  2009-05-07       Impact factor: 8.606

6.  Differential mechanisms of neuroprotection by 17 beta-estradiol in apoptotic versus necrotic neurodegeneration.

Authors:  C Harms; M Lautenschlager; A Bergk; J Katchanov; D Freyer; K Kapinya; U Herwig; D Megow; U Dirnagl; J R Weber; H Hörtnagl
Journal:  J Neurosci       Date:  2001-04-15       Impact factor: 6.167

Review 7.  Sex differences in cognitive impairment and Alzheimer's disease.

Authors:  Rena Li; Meharvan Singh
Journal:  Front Neuroendocrinol       Date:  2014-01-13       Impact factor: 8.606

8.  Estradiol mitigates ischemia reperfusion-induced acute renal failure through NMDA receptor antagonism in rats.

Authors:  Amrit Pal Singh; Nirmal Singh; Preet Mohinder Singh Bedi
Journal:  Mol Cell Biochem       Date:  2017-04-21       Impact factor: 3.396

9.  Levels of estrogen receptors alpha and beta in frontal cortex of patients with Alzheimer's disease: relationship to Mini-Mental State Examination scores.

Authors:  Jeremiah F Kelly; Julia L Bienias; Avni Shah; Kathleen A Meeke; Julie A Schneider; Edwin Soriano; David A Bennett
Journal:  Curr Alzheimer Res       Date:  2008-02       Impact factor: 3.498

10.  Estrogen receptor alpha inhibits the estrogen-mediated suppression of HIV transcription in astrocytes: implications for estrogen neuroprotection in HIV dementia.

Authors:  Paula M Heron; Jadwiga Turchan-Cholewo; Annadora J Bruce-Keller; Melinda E Wilson
Journal:  AIDS Res Hum Retroviruses       Date:  2009-11       Impact factor: 2.205
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.