Literature DB >> 9249019

High-molecular-mass complexes of human minichromosome-maintenance proteins in mitotic cells.

A Richter1, R Knippers.   

Abstract

Minichromosome-maintenance (Mcm) proteins perform essential functions regulating the replication of eukaryotic genomes. In interphase cells they are either bound to a nuclear structure, most probably chromatin, or occur as free multiprotein complexes in the nucleoplasm. Mcm proteins are displaced from their chromatin sites during S phase, and several become highly phosphorylated during mitosis. We investigated whether phosphorylation affects the ability of mitotic Mcm proteins to form multiprotein complexes. Our results clearly show that phosphorylated mitotic Mcm proteins form a 14-15-S complex, probably consisting of one molecule each of the six known human Mcm proteins.

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Year:  1997        PMID： 9249019     DOI： 10.1111/j.1432-1033.1997.00136.x

Source DB:  PubMed          Journal:  Eur J Biochem        ISSN： 0014-2956


  11 in total

1.  Identification of two residues in MCM5 critical for the assembly of MCM complexes and Stat1-mediated transcription activation in response to IFN-gamma.

Authors:  C J DaFonseca; F Shu; J J Zhang
Journal:  Proc Natl Acad Sci U S A       Date:  2001-03-06       Impact factor: 11.205

2.  MCM proteins are associated with RNA polymerase II holoenzyme.

Authors:  K Yankulov; I Todorov; P Romanowski; D Licatalosi; K Cilli; S McCracken; R Laskey; D L Bentley
Journal:  Mol Cell Biol       Date:  1999-09       Impact factor: 4.272

3.  Biochemical analysis of the intrinsic Mcm4-Mcm6-mcm7 DNA helicase activity.

Authors:  Z You; Y Komamura; Y Ishimi
Journal:  Mol Cell Biol       Date:  1999-12       Impact factor: 4.272

4.  A double-hexamer archaeal minichromosome maintenance protein is an ATP-dependent DNA helicase.

Authors:  J P Chong; M K Hayashi; M N Simon; R M Xu; B Stillman
Journal:  Proc Natl Acad Sci U S A       Date:  2000-02-15       Impact factor: 11.205

5.  Ser727-dependent recruitment of MCM5 by Stat1alpha in IFN-gamma-induced transcriptional activation.

Authors:  J J Zhang; Y Zhao; B T Chait; W W Lathem; M Ritzi; R Knippers; J E Darnell
Journal:  EMBO J       Date:  1998-12-01       Impact factor: 11.598

6.  Identification and functional characterization of a new member of the human Mcm protein family: hMcm8.

Authors:  Devrim Gozuacik; Mounia Chami; David Lagorce; Jamila Faivre; Yoshiki Murakami; Olivier Poch; Esther Biermann; Rolf Knippers; Christian Bréchot; Patrizia Paterlini-Bréchot
Journal:  Nucleic Acids Res       Date:  2003-01-15       Impact factor: 16.971

7.  Sequential MCM/P1 subcomplex assembly is required to form a heterohexamer with replication licensing activity.

Authors:  T A Prokhorova; J J Blow
Journal:  J Biol Chem       Date:  2000-01-28       Impact factor: 5.157

8.  Mcm2, but not RPA, is a component of the mammalian early G1-phase prereplication complex.

Authors:  D S Dimitrova; I T Todorov; T Melendy; D M Gilbert
Journal:  J Cell Biol       Date:  1999-08-23       Impact factor: 10.539

9.  Expression, purification and biochemical characterization of Schizosaccharomyces pombe Mcm4, 6 and 7.

Authors:  Meng Xu; Y Paul Chang; Xiaojiang S Chen
Journal:  BMC Biochem       Date:  2013-02-27       Impact factor: 4.059

10.  Minichromosome maintenance proteins 2 and 5 in non-benign epithelial ovarian tumours: relationship with cell cycle regulators and prognostic implications.

Authors:  H Gakiopoulou; P Korkolopoulou; G Levidou; I Thymara; A Saetta; C Piperi; N Givalos; I Vassilopoulos; K Ventouri; A Tsenga; A Bamias; M-A Dimopoulos; E Agapitos; E Patsouris
Journal:  Br J Cancer       Date:  2007-10-16       Impact factor: 7.640
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