Literature DB >> 9247892

Is breast cancer caused by late exposure to a common virus?

A Richardson1.   

Abstract

Although there are recognized risk factors for breast cancer, its cause is still unknown. It is hypothesized here that breast cancer results from late exposure to a common virus. This hypothesis is investigated by relating the epidemiology of breast cancer to the seroepidemiology of cytomegalovirus, as a surrogate for a breast cancer virus. The hypothesis is consistent with the geographical distribution of breast cancer; a correlation between breast cancer incidence and the percentage of adults who are cytomegalovirus seropositive in various countries was found (Pearson correlation coefficient -0.79). The hypothesis is also consistent with other risk factors for breast cancer, such as age at onset, family history, hormonal factors and migration.

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Year:  1997        PMID: 9247892     DOI: 10.1016/s0306-9877(97)90118-3

Source DB:  PubMed          Journal:  Med Hypotheses        ISSN: 0306-9877            Impact factor:   1.538


  23 in total

Review 1.  Breast cancer hypothesis: a single cause for the majority of cases.

Authors:  R A Wiseman
Journal:  J Epidemiol Community Health       Date:  2000-11       Impact factor: 3.710

2.  Relationship between viral factors, axillary lymph node status and survival in breast cancer.

Authors:  Ju-Hsin Tsai; Chun-Sen Hsu; Chung-Hung Tsai; Jang-Ming Su; Yin-Tso Liu; Min-Hsiung Cheng; James Cheng-Chung Wei; Fong-Lin Chen; Chi-Chiang Yang
Journal:  J Cancer Res Clin Oncol       Date:  2006-07-25       Impact factor: 4.553

Review 3.  Breast cancer and cytomegalovirus.

Authors:  A K Richardson; L C Walker; B Cox; H Rollag; B A Robinson; H Morrin; J F Pearson; J D Potter; M Paterson; H-M Surcel; E Pukkala; M J Currie
Journal:  Clin Transl Oncol       Date:  2019-06-29       Impact factor: 3.405

4.  Case report of concurrent primary malignancies of the breast and nasopharynx.

Authors:  Xinbin Pan; Xiaodong Zhu; Qingdi Quentin Li
Journal:  Oncol Lett       Date:  2012-05-15       Impact factor: 2.967

5.  Breast cancer, cytomegalovirus and Epstein-Barr virus: a nested case-control study.

Authors:  B Cox; A Richardson; P Graham; R E Gislefoss; E Jellum; H Rollag
Journal:  Br J Cancer       Date:  2010-04-20       Impact factor: 7.640

Review 6.  Possible association between hepatitis C virus and malignancies different from hepatocellular carcinoma: A systematic review.

Authors:  Sirio Fiorino; Letizia Bacchi-Reggiani; Dario de Biase; Adele Fornelli; Michele Masetti; Andrea Tura; Fabio Grizzi; Matteo Zanello; Laura Mastrangelo; Raffaele Lombardi; Giorgia Acquaviva; Luca di Tommaso; Arrigo Bondi; Michela Visani; Sergio Sabbatani; Laura Pontoriero; Carlo Fabbri; Andrea Cuppini; Annalisa Pession; Elio Jovine
Journal:  World J Gastroenterol       Date:  2015-12-07       Impact factor: 5.742

7.  Detection of human cytomegalovirus in normal and neoplastic breast epithelium.

Authors:  Lualhati E Harkins; Lisa A Matlaf; Liliana Soroceanu; Katrin Klemm; William J Britt; Wenquan Wang; Kirby I Bland; Charles S Cobbs
Journal:  Herpesviridae       Date:  2010-12-23

8.  Association between chronic viral hepatitis infection and breast cancer risk: a nationwide population-based case-control study.

Authors:  Fu-Hsiung Su; Shih-Ni Chang; Pei-Chun Chen; Fung-Chang Sung; Chien-Tien Su; Chih-Ching Yeh
Journal:  BMC Cancer       Date:  2011-11-24       Impact factor: 4.430

9.  Productive Infection of Human Breast Cancer Cell Lines with Human Cytomegalovirus (HCMV).

Authors:  Kaitlin M Branch; Erica C Garcia; Yin Maggie Chen; Matthew McGregor; Mikayla Min; Rachel Prosser; Natalia Whitney; Juliet V Spencer
Journal:  Pathogens       Date:  2021-05-23

10.  High prevalence of human cytomegalovirus proteins and nucleic acids in primary breast cancer and metastatic sentinel lymph nodes.

Authors:  Chato Taher; Jana de Boniface; Abdul-Aleem Mohammad; Piotr Religa; Johan Hartman; Koon-Chu Yaiw; Jan Frisell; Afsar Rahbar; Cecilia Söderberg-Naucler
Journal:  PLoS One       Date:  2013-02-22       Impact factor: 3.240

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