Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Modulation of delayed-type hypersensitivity and cellular immunity to microbial vaccines: effects of cyclophosphamide on the immune response to tularemia vaccine.

Literature DB >> 924675

Modulation of delayed-type hypersensitivity and cellular immunity to microbial vaccines: effects of cyclophosphamide on the immune response to tularemia vaccine.

Abstract

Treatment of guinea pigs with cyclophosphamide before immunization with killed tularemia vaccine in Freund incomplete adjuvant produced a prolongation and intensification of delayed-type hypersensitivity and in vitro lymphocyte transformation reactions to tularemia antigen. Such reactions resemble those ordinarily associated with the administration of live tularemia vaccine, killed vaccine in Freund complete adjuvant, or recovery from natural infection. The immunopotentiation lasted longer than that seen previously in other antigenic systems with this drug and was dependent on the dose of vaccine used. More intense delayed skin reactivity could be transferred into normal controls by cells from immunized donors pretreated with cyclophosphamide than by cells from immunized donors that were not pretreated.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 1977 PMID： 924675 PMCID： PMC421233 DOI： 10.1128/iai.18.2.318-323.1977

Source DB: PubMed Journal: Infect Immun ISSN： 0019-9567 Impact factor: 3.441

33 in total

1. Studies on the relationship of delayed hypersensitivity to immunity in tularemia.

Authors: M GORDON
Journal: J Immunol Date: 1963-02 Impact factor: 5.422

2. Prophylactic effectiveness of live and killed tularemia vaccines. I. Production of vaccine and evaluation in the white mouse and guinea pig.

Authors: H T EIGELSBACH; C M DOWNS
Journal: J Immunol Date: 1961-10 Impact factor: 5.422

3. Tularemia vaccine study. II. Respiratory challenge.

Authors: S SASLAW; H T EIGELSBACH; J A PRIOR; H E WILSON; S CARHART
Journal: Arch Intern Med Date: 1961-05

4. Tularemia vaccine study. I. Intracutaneous challenge.

Authors: S SASLAW; H T EIGELSBACH; H E WILSON; J A PRIOR; S CARHART
Journal: Arch Intern Med Date: 1961-05

5. Vaccine Prophylaxis against Tularemia in Man.

Authors: L Foshay; W H Hesselbrock; H J Wittenberg; A H Rodenberg
Journal: Am J Public Health Nations Health Date: 1942-10

6. Studies on tularemia. V. Immunization of man.

Authors: P J KADULL; H R REAMES; L L CORIELL; L FOSHAY
Journal: J Immunol Date: 1950-10 Impact factor: 5.422

7. Cyclophosphamide-potentiated West Nile viral encephalitis: relative influence of cellular and humoral factors.

Authors: D L Camenga; N Nathanson; G A Cole
Journal: J Infect Dis Date: 1974-12 Impact factor: 5.226

8. The relation of immune depression and B-cell stimulation during the development of delayed hypersensitivity to soluble antigens.

Authors: R J Scheper; D Parker; B Noble; J L Turk
Journal: Immunology Date: 1977-02 Impact factor: 7.397

9. The effect of cyclophosphamide on the recovery from a local chlamydial infection. Guinea-pig inclusion conjunctivitis (GPIC).

Authors: F Modabber; S E Bear; J Cerny
Journal: Immunology Date: 1976-06 Impact factor: 7.397

10. The value of an assessment of erythema and increase in thickness of the skin reaction for a full appreciation of the nature of delayed hypersensitivity in the guinea pig.

Authors: R J Scheper; B Noble; D Parker; J L Turk
Journal: Int Arch Allergy Appl Immunol Date: 1977

6 in total

5. Mechanisms of protective immunogenicity of microbial vaccines: effects of cyclophosphamide pretreatment in Venezuelan encephalitis, Q fever and tularaemia.

Authors: M S Ascher; P B Jahrling; D G Harrington; R A Kishimoto; V G McGann
Journal: Clin Exp Immunol Date: 1980-08 Impact factor: 4.330

6. Relation between delayed hypersensitivity and cell-mediated immunity.

Authors: J L Turk
Journal: J R Soc Med Date: 1979-04 Impact factor: 18.000